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甜梦口服液治疗利培酮所致女性精神分裂症患者高泌乳素血症的临床研究

Clinical study on Tianmeng Oral Liquid in treatment of hyperprolactinemia caused by risperidone in female schizophrenia
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摘要 目的探讨甜梦口服液治疗利培酮所致女性精神分裂症患者高泌乳素血症的临床效果。方法按随机数字表法将2016年1月一2017年6月天津市安定医院接诊的90例利培酮所致女性精神分裂症患者高泌乳素血症分为两组。对照组45例患者维持原有利培酮剂量不变,治疗组联合使用甜梦口服液治疗。连续治疗8周后,比较两组患者血清泌乳素(PRL)水平、阳性与阴性症状量表(PANSS)评分、治疗副反应量表(TESS)评分、临床总体印象量表(CGI)评分、桡骨骨密度、临床疗效以及用药安全性。结果治疗组血清PRL水平为(80.64±35.12)ng/mL,低于对照组[(145.46±45.73)ng/mL],差异显著(P<O.05);治疗后治疗组患者阳性症状、阴性症状、精神病理评分和总分均明显低于对照组,差异显著(P<0.05);治疗后治疗组TESS评分、CGI评分分别为(2.64±1.25)分、(1.54±0.47)分,对照组TESS评分、CGI评分分别为.(4.27±3.16)分、(2.39±0.66)分,治疗组TESS评分、CGI评分均低于对照组,差异显著(P<0.05、0.01);治疗后治疗组桡骨骨密度为(-0.27±1.46)SD高于对照组的(-0.95±0.86)SD,差异显著(P<0.01);治疗组总有效率为73.33%,明显高于对照组的53.33%,差异显著(P<0.05);两组患者治疗期间心电图以及心率、血压等生命体征均无明显异常。结论甜梦口服液可以改善利培酮所致女性精神分裂症患者高泌乳素血症,有效降低血清PRL水平,提高桡骨骨密度,改善月经不调和溢乳情况,且无明显副作用,安全性较高。 Objective To investigate the clinical effect of Tianmeng Oral Liquid in treatment of hyperprolactinemia caused by risperidone in female schizophrenia. Methods A total of 90 cases of hyperprolactinemia caused by risperidone in female schizophrenia in Tianjin Anding Hospital from January 2016 to June 2017 were divided into two groups by random number table. Patients in the control group(n = 45) were given ordinary dose of risperidone, while patients in the treatment group were treated with the combination of Tianmeng Oral Liquid and risperidone. After eight weeks of treatment, the level of prolactin(PRL), positive and negative syndrome scale(PANSS), treatment emergent symptom scale(TESS), clinical global impression(CGI), bone mineral density of radius, clinical efficacy, and safety of medication were compared between two groups. Results The level of PRL in treatment group [(80.64 ± 35.12) ng/mL] was lower than control group [(145.46 ± 45.73) ng/m L](P < 0.05); The scores of positive syndrome, negative syndrome, psychopathology, and total scores in control group were higher than those in treatment group(P < 0.05); The scores of TESS and CGI in treatment group [(2.64 ± 1.25) points,(1.54 ± 0.47) points] were lower than control group [(4.27 ± 3.16) points,(2.39 ± 0.66) points](P < 0.05); The bone mineral density of radius in treatment group [(-0.27 ± 1.46) SD] was higher than control group [(-0.95 ± 0.86) SD](P < 0.05); The total effective rate of treatment group [73.33%(33/45)] was higher than control group [53.33%(24/45)](P < 0.05); There were no abnormal electrocardiogram, heart rate, blood pressure in two groups during treatment. Conclusion Tianmeng Oral Liquid in treatment of hyperprolactinemia caused by risperidone in female schizophrenia is effective, it can decrease the level of PRL, increase bone mineral density of radius, improve irregular menstruation and galactorrhea, and have higher safety without obvious side effects.
作者 林虹 于志峰 陈红昊 王志凌 李育红 武学润 LIN Hong;YU Zhi-feng;CHEN Hong-hao;WANG Zhi-ling;LI Yu-hong;WU Xue-run(Tianjin Anding Hospital,Tianjin 300222,China;Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
出处 《中草药》 CSCD 北大核心 2018年第22期5373-5377,共5页 Chinese Traditional and Herbal Drugs
关键词 甜梦口服液 精神分裂症 抗精神病药物 高泌乳素血症 利培酮 Tianmeng Oral Liquid schizophrenia antipsychotics hyperprolactinemia risperidone
作者简介 林虹(1968一),女,主任医师,研究方向为中西医结合治疗精神系统疾病:Tel:13512447470E-mail:lililin929@163.com;通信作者,于志峰,副研究员。E-mail:fengzhiyu86@hotmail.com.
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