Objective To investigate the clinical effect of Tianmeng Oral Liquid in treatment of hyperprolactinemia caused by risperidone in female schizophrenia. Methods A total of 90 cases of hyperprolactinemia caused by risperidone in female schizophrenia in Tianjin Anding Hospital from January 2016 to June 2017 were divided into two groups by random number table. Patients in the control group(n = 45) were given ordinary dose of risperidone, while patients in the treatment group were treated with the combination of Tianmeng Oral Liquid and risperidone. After eight weeks of treatment, the level of prolactin(PRL), positive and negative syndrome scale(PANSS), treatment emergent symptom scale(TESS), clinical global impression(CGI), bone mineral density of radius, clinical efficacy, and safety of medication were compared between two groups. Results The level of PRL in treatment group [(80.64 ± 35.12) ng/mL] was lower than control group [(145.46 ± 45.73) ng/m L](P < 0.05); The scores of positive syndrome, negative syndrome, psychopathology, and total scores in control group were higher than those in treatment group(P < 0.05); The scores of TESS and CGI in treatment group [(2.64 ± 1.25) points,(1.54 ± 0.47) points] were lower than control group [(4.27 ± 3.16) points,(2.39 ± 0.66) points](P < 0.05); The bone mineral density of radius in treatment group [(-0.27 ± 1.46) SD] was higher than control group [(-0.95 ± 0.86) SD](P < 0.05); The total effective rate of treatment group [73.33%(33/45)] was higher than control group [53.33%(24/45)](P < 0.05); There were no abnormal electrocardiogram, heart rate, blood pressure in two groups during treatment. Conclusion Tianmeng Oral Liquid in treatment of hyperprolactinemia caused by risperidone in female schizophrenia is effective, it can decrease the level of PRL, increase bone mineral density of radius, improve irregular menstruation and galactorrhea, and have higher safety without obvious side effects.
Chinese Traditional and Herbal Drugs