Objective To analyze the therapeutic effect of low-molecular-weight heparin sodium in elderly patients who suffering from acute exacerbation of chronic obstructive pulmonary disease( AECOPD) with elevated D-dimer. Method 88 elderly AECOPD patients with elevated D-dimer were randomly divided into observation group and control group,44 cases in each group. Patients in the control group were given anti-inflammatory, expectorant, antispasmodic, antiasthmatic, oxygen inhalation and other conventional treatment, while patients in the observation group were given low-molecular-weight heparin sodium subcutaneous injection treatment in addition to the same conventional treatment. Both two groups were treated for 7 days. The differences of D-dimer, coagulation function, arterial blood gas analysis and pulmonary function between the two groups were observed and compared. Result There was no significant difference in baseline data of sex and age between the two groups(P>0.05). After treatment, D-dimer, arterial oxygen partial pressure( PaO2), carbon dioxide partial pressure( PaCO2), first second forced expiratory volume(FEV1%) and first second forced expiratory volume/forced vital capacity(FEV1/FVC) of the two groups were all improved( P<0.05), and the indexes of the observation group were obviously improved(P<0.05).There was no significant difference in fibrinogen(FgB), prothrombin time(PT) and partially activated prothrombin time(APTT) in the control group before and after treatment. No obvious adverse drug reactions induced by low-molecular-weight heparin were found in the observation group. Conclusion In elderly patients with AECOPD, low-molecular-weight heparin sodium anticoagulant therapy can significantly reduce D-dimer, improve blood gas analysis, coagulation status and respiratory function, and has safety, which is worthy of clinical application.
Chinese Journal For Clinicians
Acute exacerbation of chronic obstructive pulmonary disease
Low-molecular-weight heparin sodium