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电针合雷火灸对癌痛镇痛作用及β - EP、PGE2的影响

Analgesic Effect of Electro - Acupuncture Combined with Thunder - Fire Moxibustionand Its Influence to β- EP and PGE2 in the Treatment of Cancer Pain
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摘要 目的:循经取癌痛相关脏腑经络的原穴、络穴和郄穴,采用电针合雷火灸干预方式,观察对癌痛患者镇痛作用及对外周血β-EP、PGE2的影响。方法:共观察90例患者,随机分为循经电针合雷火灸组、局部取穴组和药物组,每组各30例,治疗后应用VAS疼痛视觉指数表评分、镇痛起效时间、镇痛持续时间、外周血β-EP、PGE2含量为观察指标进行临床观察研究。结果:循经电针合雷火灸组镇痛效果最佳,优于局部取穴组(P<0.05);与药物组相比,差异无统计学意义(P>0.05)。循经电针合雷火灸组镇痛起效时间最快,与局部取穴组比较,差异有统计学意义(P<0.05),与药物组对比,差异有显著统计学意义(P<0.01)。循经电针合雷火灸组镇痛持续时间较局部取穴组长,差异有统计学意义(P<0.05);与药物组差异无统计学意义(P>0.05)。治疗后循经电针合雷火灸组外周血β-EP水平影响与局部取穴组比较,差异有统计学意义(P<0.05);与药物组相比,差异无统计学意义(P>0.05)。循经电针合雷火灸组对外周血PGE2影响与局部取穴组相比,差异有统计学意义(P<0.05);与药物组相比,差异无统计学意义(P>0.05)。结论:循经电针合雷火灸对癌痛患者镇痛效果最佳,起效时间最快,镇痛持续时间与止痛药物治疗接近,对外周血β-EP和PGE2含量的影响与三阶梯止痛药物治疗无明显差异。 Objective:To observe the analgesic effect of electro - acupuncture combined with thunder - firemoxibustion on Yuan - source acupoint,Luo - connecting acupoint,and Xi - cleft acupoint of the related me-ridian in the treatment of cancer pain,and to observe its influence to β - EP and PGE2 in peripheral blood.Methods:90 patients were randomly divided into the combination group(thunder - fire moxibustion + electro -acupuncture),the local acupoints group,and the medication group,with 30 cases in each group. Cancer Pain(graded by VAS),onset time of analgesia,duration of analgesia,and the contents of β - EP and PGE2 wereobserved and compared in the groups. Results:In terms of analgesic effect,the combination group showed besteffect,which was better than the local acupoints group(P <0. 05); however,there was no statistical differencebetween the combination group and the medication group(P >0. 05). In terms of the onset time of analgesia,the combination group had the shortest onset time,which was shorter than the local acupoints group(P <0. 05),and shorter than the medication group(P <0. 01). In terms of the duration of analgesia,the combina-tion group showed longer effect than the local acupoints group did(P <0. 05); however,there was no statisticaldifference between the combination group and the medication group(P > 0. 05). In terms of the influence toβ - EP and PGE2,there was significant difference between the combination group and the local acupoints group(P <0. 05); but no significant difference was seen between the combination group and the medication group(P >0. 05). Conclusion:Electro - acupuncture combined with thunder - fire moxibustion had best analgesiceffect,with its fastest onset time of analgesia and the longest duration of analgesia,in patients suffering fromcancer pain,which showed similar effect to pain killer. There was no significant difference in the influence toβ - EP and PGE2 when compared to the three ladder acesodyne medication.
作者 韦日铺 蒋云芳 李扬帆 WEI Ripu;JIANG Yunfang;LI Yangfan(Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,China;Guangxi University of Chinese Medicine,Nanning 530001,China)
出处 《针灸临床杂志》 2018年第11期10-14,共5页 Journal of Clinical Acupuncture and Moxibustion
基金 广西自然基金面上项目,编号:2015GXNSFAA139149.
关键词 电针 雷火灸 特定穴 癌痛 镇痛作用 β-EP PGE2 Electro - acupuncture Thunder - fire moxibustion Specific acupoint Cancer pain Analgesiceffect β - EP PGE2
作者简介 韦日铺(1985 - ),男,主治医师,主要从事针灸治疗肺系疾病及痛症的临床和实验研究。
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