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雷公藤红素对糖尿病大鼠的肾脏保护作用

Protective Effect of Celastrol on Kidney in Diabetic Rats
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摘要 目的:研究不同剂量雷公藤红素对糖尿病大鼠肾脏的保护作用。方法:1%链脲佐菌素(STZ)(50mg/g)腹腔注射制备糖尿病模型,模型制备成功后分为对照组、模型组、雷公藤素高剂量组、雷公藤素低剂量组。连续给药4周后,观察大鼠一般情况、体质量、肾脏指数、肝脏指数、24h尿量、尿蛋白及肝肾血清生化指标。结果:与对照组比较,模型组大鼠表现为多饮、多食、多尿及体质量下降,肝脏指数、血尿素氮、血肌酐、24h尿量、24h尿蛋白含量均明显升高(P<0.05);与模型组比较,给药组可改善糖尿病大鼠多饮、多食、多尿的症状,增加大鼠体质量,雷公藤红素给药组体质量、肝脏指数、血肌酐、血尿素氮、24h尿量、24h尿微量白蛋白、24h尿蛋白、FN含量均有不同程度降低(P<0.05)。结论:雷公藤红素对糖尿病大鼠肾脏有一定的保护作用,能够延缓糖尿病肾病的发生及进展。 Objective:To study the effects of different doses of celastrol on renal function of diabetic rats. Methods:Diabetes mellitus model was established by intraperitoneal injection of 1% streptozotocin (STZ)50mg/kg. After successful preparation,the model was divided into blank group,model group,high dose group and low dose group.After 4weeks of continuous administration,observe the general condition of rats,body weight,kidney index,liver index.24h urine volume,urine protein and serum biochemical indexes of liver and kidney. Results:Compared with the control group,the rats in the model group showed more food for polydipsia,polyuria,and decreased body weight,liver index,blood urea nitrogen,serum creatinine,24h urine volume,24h urinary protein content was significantly increased (P<0.05);compared with the model group,the two drug groups can improve polydipsia,diabetes rats eat,polyuria symptoms,increase body weight of the rats,celastrol groups weight,liver index,serum creatinine,blood urea nitrogen,24h urine volume,24h urinary albumin,24h urinary protein,decreased the content of FN (P<0.05).Conclusions:Celastrol had a protective effect on the kidney of diabetic rats,can delay the occurrence and progression of diabetic nephropathy.
作者 张敏 颜苗 樊新荣 谢辉 张玲 聂钰松 ZHANG Min;YAN Miao;FAN Xin-Rong;XIE Hui;ZHANG Ling;NIE Yu-song(Shaanxi University of Chinese Medicine,Xianyang Shaanxi,712046China;Department of Pharmacy,The Second Xiangya Hospital,Central South University,Changsha Hu'nan 410011,China;China Aeademy of Chinese Medical Sciences,Beijing 100700,China;Hu'nan University of Chinese Medicine,Changsha Hu'nan 410208,China)
出处 《中医药导报》 2018年第24期85-87,91共4页 GUIDING JOURNAL OF TCM
基金 国家自然科学基金资助项目(81373708,81202985) 国家中医药行业科研专项项目(201407004).
关键词 雷公藤红素 糖尿病 肾脏保护 大鼠 ccelastrol diabetic reno-protect rats
作者简介 通讯作者:樊新荣,E-mail:fxr1973@126.com
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