目的检测三氯乙烯对受试动物致突变作用.方法以不同剂量的三氯乙烯染毒实验动物,经口灌胃给予受试物,用30 h给受试物法,即两次给受试物间隙24 h,第2日给受试物后6 h处死动物,制片,观察并计数嗜多染红细胞的微核率,并与阳性对照组和阴性对照组进行比较分析.结果与阴性对照组相比,各剂量组的微核率差异无显著性(P＞0.05)结论三氯乙烯小鼠骨髓嗜多染红细胞微核试验结果阴性.
[Objective] To investigate mutational function of trichloroethylene(TCE) on the mice. [Methods] The mice were divided into five groups including a positive group, a negative group and three poisoning groups. The mice received TCE twice through gavage by 30h method (24 hrs' interval between 2 times) . Sliders were made, polychromatic erythrocyte ( PCE) was observed and rates of their micronucleus were counted and were compared with positive and negative group respectively. [Results] Compared with the negative group, no significant difference was found in micronucleus. ( P > 0.05) [Conclusion] TCE couldn't promote rates of micronucleus of PCE in
Occupation and Health
polychromatic erythrocyte (PCE)