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三氯乙烯染毒小鼠骨髓微核试验观察 预览 被引量:1

Observation on the bone barrow micro - nuclear experiment on the trichloroethylene- infected mice
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摘要 目的检测三氯乙烯对受试动物致突变作用.方法以不同剂量的三氯乙烯染毒实验动物,经口灌胃给予受试物,用30 h给受试物法,即两次给受试物间隙24 h,第2日给受试物后6 h处死动物,制片,观察并计数嗜多染红细胞的微核率,并与阳性对照组和阴性对照组进行比较分析.结果与阴性对照组相比,各剂量组的微核率差异无显著性(P>0.05)结论三氯乙烯小鼠骨髓嗜多染红细胞微核试验结果阴性. [Objective] To investigate mutational function of trichloroethylene(TCE) on the mice. [Methods] The mice were divided into five groups including a positive group, a negative group and three poisoning groups. The mice received TCE twice through gavage by 30h method (24 hrs' interval between 2 times) . Sliders were made, polychromatic erythrocyte ( PCE) was observed and rates of their micronucleus were counted and were compared with positive and negative group respectively. [Results] Compared with the negative group, no significant difference was found in micronucleus. ( P > 0.05) [Conclusion] TCE couldn't promote rates of micronucleus of PCE in
作者 黄海雄 张锦周 黄钰 庄志雄 张炳尧 慈捷元 HUANG Haixiong, ZHANG Jinzhou ( Shen Zhen Hygiene And Anti - epidemic station , 518020)
出处 《职业与健康》 CAS 2002年第4期 35-36,共2页 Occupation and Health
关键词 三氯乙烯 嗜多染红细胞 微核 trichloroethylene(TCE) polychromatic erythrocyte (PCE) micronucleus
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