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泰兴市乙型肝炎表面抗原家庭聚集性研究 预览 被引量:1

Study on familial clustering of HBsAg in Taixing
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摘要 目的 探讨泰兴市乙型肝炎(乙肝)表面抗原(HBsAg)分布是否有家庭聚集性,为今后乙肝的防制工作提供依据.方法 利用乙肝流行病学抽样调查方法调查泰兴市4 745户家庭,其中有1 565例乙肝表面抗原阳性病例,分布在1 309户家庭中.本研究针对该数据,分别采用负二项分布和二项分布的方法进行拟合.如果服从负二项分布或不服从二项分布,则乙肝表面抗原的分布呈家庭聚集性.结果 经负二项分布和二项分布模型拟合,所得统计学检验分别为P>0.05和P<0.05,说明乙肝表面抗原分布服从负二项分布,不服从负二项分布.结论 泰兴市乙肝表面抗原的分布有家庭聚集性,实施母婴阻断和加强乙肝疫苗免疫接种可缓解乙肝家庭聚集现象. Objective To study familial clustering of HBsAg in Taixing, and provide evidence for the prevention and control of HBV. Methods A total of 4 745 families took part in this study and cases distribution was analyzed by using epidemiological sampling survey. There were 1 565 persons with positive HBsAg distributed in 1 309 families. The data was analyzed by fitting negative binomial distribution and binomial distribution. If the data follows negative binomial distribution and doesn't follow binomial distribution, then HBsAg distribution has a phenomenon of familiar aggregation. Results P Values for fitting negative binomial distribution were greater than 0. 05, which indicated the data did follow negative binomial distribution. P Values for fitting binomial distribution were less than 0.05, which indicated the data did not follow binomial distribution. Conclusion HBsAg in Taixing has a phenomenon of familial aggregation.
作者 孙翔 翟祥军 马福宝 SUN Xiang, ZAI Xiang-jun, MA Fu-bao (Jiangsu Province Center for Disease Control and Prevention, Nanjing 210009, China)
出处 《江苏预防医学》 CAS 2014年第4期18-20,共3页 Jiangsu Journal of Preventive Medicine
关键词 负二项分布 二项分布 乙肝表面抗原 家庭聚集性 negative binomial distribution binomial distribution HBsAg familial aggregation
作者简介 孙翔(1984-),江苏镇江人,医师,主要从事传染病预防控制工作.
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