目的了解江苏省健康人群脊髓灰质炎中和抗体水平,为及时制定免疫策略、维持无脊灰状态提供科学依据。方法采取江苏省2009年-2013年健康人群血清标本,应用细胞中和实验法检测脊灰中和抗体。SPSS 18.0统计软件进行统计分析。结果共检测3 000名健康人群的血清标本,脊灰Ⅰ、Ⅱ、Ⅲ型抗体阳性率分别为98.51%、98.37%、94.97%;几何平均滴度（GMT）分别为1∶186.21、1∶125.89、1∶47.86;不同年份健康人群脊灰抗体阳性率和GMT无统计学意义（P〉0.05）;不同年龄段健康人群脊灰抗体阳性率及GMT有统计学意义（P〈0.05）,抗体水平总趋势随年龄增长递减。结论江苏省健康人群脊灰抗体阳性率和几何平均滴度,近5年均保持在较高水平,接种脊灰疫苗可获得较好的免疫保护。今后应继续保持高水平的免疫覆盖率,进一步改进免疫策略及提高AFP病例监测系统的敏感性,巩固无脊灰成果。
Objective To investigate neutralizing antibodies level of the poliomyelitis among healthy people against polio in Jiangsu province during 2009 -2013, and provide scientific evidence for making the immunization strategy and sustain the polio level. Methods The healthy people were randomly enrolled from Jiangsu province. The poliomyelitis antibody level of were de- tected by cells neutralization test. SPSS software was used for statistical analysis. Results The neutralizing antibody positive rates for polio I , I1 , 11 were 98.51% ,98.37% ,94.97% respectively; the geometric mean antibody titers （GMTs） were 1 ＂ 186.21, 1 ＂ 125.89, 1 ： 47.86 respectively of 3000 serum specimens in Jiangsu province during 2009 - 2013. There were no significant differences in antibody levels between different years. But the GMTs were significantly associated with ages （ P 〈 0.05）, which was decreased with the age increasing. Conclusion The poliomyelitis antibody positive rates and GMTs are still maintaining a high -level in Jiangsu and the firm immune protective barrier had been built against poliomyelitis among healthy people.
Chinses Journal of Health Laboratory Technology