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2010年-2013年江苏省健康儿童水痘-带状疱疹病毒抗体水平监测分析 被引量:4

Detection and analysis of Varicella- Zoster virus Ig G antibody levels in healthy children in Jiangsu province in 2010-2013
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摘要 目的检测江苏省健康儿童水痘-带状疱疹病毒抗体水平,了解水痘疫苗的免疫效果,为水痘的免疫学策略制定提供科学依据。方法采用随机抽样的方式抽取2010年-2013年度扬州、连云港、泰州和常州4市7岁以下健康儿童400名,采用酶联免疫吸附试验(ELISA)测定水痘-带状疱疹病毒免疫球蛋白G(Ig G)抗体。采用SPSS 18.0统计软件进行统计分析。结果共检测400名健康儿童的血清标本,水痘-带状疱疹病毒Ig G抗体总阳性率为65.00%,抗体浓度均值为231.26 m IU/ml。不同年龄段健康儿童脊灰抗体阳性率差异有统计学意义。有水痘疫苗免疫史的健康儿童的抗体阳性率及抗体平均浓度均明显高于无免疫史的儿童。不同地区、不同年份健康儿童体内水痘-带状疱疹病毒Ig G浓度以及抗体阳性率差异无统计学意义。结论接种水痘疫苗可获得较好的免疫保护。建议提高健康儿童水痘疫苗的覆盖率,同时可改变水痘疫苗免疫策略,阻止疾病的传播流行。 Objective To determine the levels of Varicella - Zoster virus (VZV) antibody among healthy children in Jiangsu province during the period of 2010 -2013, and provide scientific basis for making the immunological strategy. Methods 400 healthy children less than 7 years old were randomly selected from Yangzho, Lianyungang, Taizhou and Changzhou. The immu- noglobulin G antibodies of Varieella - Zoster virus ( VZV - IgG ) were detected by enzyme - linked immunosorbent assay (ELISA). SPSS 18.0 was used for statistical analysis. Results A total of 400 healthy children's serum specimen were tested. The overall positive rate of VZV - IgG was 65.00%. The average concentration of VZV - IgG was 231.26 mlU/ml. The positive rate of VZV - IgG in children with VZV vaccination history was significantly higher than that of the non - vaccinated group. The VZV - IgG levels were significantly associated with age( F = 3. 285, P 〈 0.05 ). There were no significant differences in VZV antibody levels between different regions. Conclusion VZV Oka vaccine ( V - Oka) vaccination can provide immunity against varicella. So it is recommended to improve the coverage of VZV vaccination among healthy children, and change immunological strategy, to prevent the outbreak of ehickenpox.
作者 吴昀 冷红英 毕诚 胡莹 邓秀英 陆培善 WU Yun, LENG Hong- ying, BI Cheng, HU Ying, DENG Xiu -ying, LU Pei -shan (Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 223002, China)
出处 《中国卫生检验杂志》 北大核心 2014年第21期3132-3134,共3页 Chinses Journal of Health Laboratory Technology
关键词 健康儿童 水痘-带状疱疹病毒Ig G抗体 阳性率 监测 Healthy children VZV-Ig G Positive rate Surveillance
作者简介 吴昀(1973-),女,硕士,主管技师,主要从事病原微生物检验及其新技术的研究。
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