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肺源性心脏病急性发作期血浆ET-1、NO水平与动脉血气分析、血液流变学及心肌酶学指标的相关性 预览

Correlation of Plasma ET-1 and NO Levels with Arterial Blood Gas Analysis, Hemorheology and Myocardial Enzymes in Acute Exacerbation of Pulmonary Heart Disease
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摘要 目的:探讨肺源性心脏病急性发作期患者血浆内皮素(ET-1)、一氧化氮(NO)水平与动脉血气分析、血液流变学及心肌酶学指标的相关性。方法选择30例肺源性心脏病急性加重期患者为观察组,分别于入院时以及治疗2周后取静脉血对血浆ET-1、NO水平及动脉血气分析、血液流变学、心肌酶谱指标进行检测;另选取30例健康体检者为对照组,对相关指标进行测定。结果观察组治疗前ET-1、NO以及心肌酶谱和血液流变学指标与对照组比较差异均有统计学意义(P〈0.05),经2周的系统治疗后,观察组各项指标较治疗前均明显改善,差异有统计学意义(P〈0.05)。 Pearson相关性分析结果显示,ET-1和NO水平与动脉血PaO2呈负相关(r=-0.567、-0.583,P〈0.05),与动脉血PaCO2、全血黏度和血浆黏度呈正相关(r=0.558、0.602、0.493,0.568、0.587、0.501;P〈0.05)。结论血浆ET-1和NO水平可作为肺源性心脏病急性加重期患者病情严重程度及判断预后的重要参考指标。 Objective To investigate the correlation of plasma endothelin-1 (ET-1) and nitric oxide (NO) levels with arterial blood gas analysis,hemorheology and myocardial enzymology in acute exacerbation of pulmonary heart disease. Methods Thirty patients with acute exacerbation of pulmonary heart disease were selected as the observation group and 30 healthy subjects as the control group. On admission to hospital and after treatment for 2 weeks, venous blood samples were drawn for the detection of plasma ET-1 and NO levels, arterial blood gas parameters, hemodynamic indexes and myocardial enzymes. Results There were significant differences in plasma ET-1 and NO levels, hemodynamic indexes and myocardial enzymes between the two groups before treatment (P〈0.05). In observation group, all indicators were obviously improved after treatment for 2 weeks (P〈0.05). Pearson correlation analysis showed that plasma ET-1 and NO levels were negatively correlated with arterial PaO2 (r=-0.567 and -0.583, respectively; P〈0.05), but positively correlated with PaCO2 (r=0.558 and 0.568, respectively; P〈0.05), blood viscosity (r=0.602 and 0.587, respectively; P〈0.05) and plasma viscosity (r=0.493 and 0.501, respectively; P〈0.05). Conclusion The levels of plasma ET-1 and NO can be used as an important reference for evaluating the severity of disease and judging the prognosis in patients with acute exacerbation of pulmonary heart disease.
作者 廖芝顺 毕君富 刘萍 陈存茂 李振华 黄秀芬 陈玉华 苏雅清 邓伟明 LIAO Zhi-shun, BI Jun-fu, LIU Ping, CHEN Cun-mao, LI Zhen-hua, HUANG Xiu-fen, CHEN Yu-hua, SU Ya-qing, DENG Wei-ming (1st Department of Internal Medicine,the Second Hospital of Zhanjiang Agricultural Reclamation, Zhanjiang 524272, China)
出处 《实用临床医学(江西)》 CAS 2014年第9期9-11,共3页 Practical Clinical Medicine
关键词 肺源性心脏病 急性发作 内皮素 一氧化氮 血液流变学 心肌酶学 动脉血气分析 pulmonary heart disease acute exacerbation endothelin nitric oxide hemorheology myocardial enzymology arterial blood gas analysis
作者简介 廖芝顺(1962-),男,学士,主治医师,主要从事肺源性心脏病的临床研究。
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