期刊文献+

帕金森病患者认知功能障碍的发生率及影响因素 预览 被引量:9

Incidence and related factors of Parkinson′s disease with cognitive dys-function
在线阅读 免费下载
收藏 分享 导出
摘要 目的:研究帕金森病( PD)患者认知功能障碍的发生率、临床特点及其相关影响因素。方法:应用蒙特利尔认知评估(MoCA)量表对52例PD患者(PD组)和58例健康对象(对照组)进行评定,探讨PD组患者认知功能障碍的发生率、临床特点及PD患者认知功能障碍与年龄、病程、H-Y分级、UPDRS评分的关系。结果:PD组Mo-CA评分(20.28±4.16)低于对照组(26.28±3.61)(t =8.036,P <0.001),PD 组患者认知功能障碍发生率(57.7%,30例)高于对照组(10.3%,6例)(χ2=19.200,P<0.001)。 PD患者认知功能障碍的主要特点表现为注意与集中、执行功能、延迟回忆、语言、视结构技能、抽象思维和定向力等下降。 Logistic回归分析显示PD组认知功能障碍与患者病情严重程度(H-Y分级)、病程、UPDRS(第1部分)评分、UPDRS(第2部分)评分有关(OR:5.464,6.172,1.138,1.305;95%CI:1.915~10.136,0.068~0.872,1.017~1.358,1.316~11.014)。结论:PD患者认知功能障碍发生率高,临床表现多样,其与病程、病情轻重、URPDS评分有关。 Aim:To study the incidence , clinical characteristics and related factors of cognitive dysfunction in Parkin-son′s disease(PD).Methods:A total of 52 patients with Parkinson′s disease (PD group) and 58 healthy patients (nor-mal group) were assessed by Montreal cognitive assessment (MoCA) scale,to study the incidence of cognitive dysfunction , clinical characteristics in PD patients and the relationship between the PD patients with cognitive dysfunction and age , du-ration, Hoehn-Yahr grade, UPDRS score.Results:The MoCA score in PD group was lower than that in normal group (t=8.036,P〈0.001), the incidence of cognitive dysfunction was 57.7% in the PD group(χ2 =19.200,P〈0.001).The main features of cognitive dysfunction in PD patients showed attention and concentration , executive functions , memory, de-layed recall, language skills, visual ability, abstract thinking and ability of orientation , retardation, etc.Logistic regression analysis showed that cognitive dysfunction in PD group was positively related with the severity of disease condition ( H-Y classification), duration, UPDRS (Part Ⅰ) score and UPDRS (Part Ⅱ) score(OR:5.464,6.172,1.138,1.305;95%CI:1.915-10.136,0.068-0.872,1.017-1.358,1.316-11.014).Conclusion: The incidence of cognitive dysfunc-tion in PD patients is high .There are many forms of clinical manifestations , and the extent of these manifestations is corre-lated with disease duration , severity and UPDRS score .
作者 赵鹏 朱红灿 李玉生 赵幸娟 郑亚珂 李薇 ZHAO Peng, ZHU Hongcan, LI Yusheng, ZHAO Xingjuan, ZHENG Yake, LI Wei( 1 )Department of Neurology, the First People ~ Hospital of Zhengzhou City, Zhengzhou 450003 2 )Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052)
出处 《郑州大学学报:医学版》 CAS 北大核心 2014年第6期869-872,共4页 Journal of Zhengzhou University: Med Sci
关键词 帕金森病 认知功能障碍 蒙特利尔认知评估 影响因素 Parkinson′s disease cognitive dysfunction Montreal cognitive assessment influence factor
作者简介 通讯作者,男,1966年4月生,博士,主任医师,研究方向:帕金森病、脑血管病的诊治,E—mail:zhc660407@hotmail.com
  • 相关文献

参考文献13

  • 1Uc EY, McDermott MP, Marder KS, et al. Incidence of andrisk factors for cognitive impairment in an early Parkinsondisease clinical trial cohort [ J ]. Neurology ,2009 ,73 (18 ):1469. 被引量:1
  • 2Vu TC , Nutt JG, Holford NH. Disease progress and re-sponse to treatment as predictors of survival, disability,cognitive impairment and depression in Parkinson's disease[J]. Br J Clin Pharmacol,2012,74(2) :284. 被引量:1
  • 3Slaughter JR, Slaughter KA, Nichols D, et al. Prevalence,clinical manifestations, etiology, and treatment of depressionin Parkinson's disease[ J ]. J Neuropsychiatry Clin Neuros-ci ,2001 ,13 (2) :187. 被引量:1
  • 4Nasreddine ZS,Phillips NA,B6dirian V,et al. The MontrealCognitive Assessment, MoCA: a brief screening tool formild cognitive impairment[ J]. J Am Geriatr Soc,2005,53(4):695. 被引量:1
  • 5中华医学会神经病学分会运动障碍及帕金森病学组.帕金森病的诊断[J].中国临床神经科学,2006,39(6):408-409. 被引量:3
  • 6Goldman JG, Ghode RA, Ouyang B, et al. Dissociations a-mong daytime sleepiness,nighttime sleep,and cognitivestatus in Parkinson's disease[ J]. Parkinsonism Relat Dis-ord ,2013 ,19(9) :806. 被引量:1
  • 7Locascio JJ,Corkin S,Growdon JH. Relation between clini-cal characteristics of Parkinson's disease and cognitive de-cline[ J]. J Clin Exp Neuropsychol,2003 ,25(1) :94. 被引量:1
  • 8Uc EY,Rizzo M , Anderson SW,et al. Visual dysfunction inParkinson disease without dementia [ J ] . Neurology, 2005 ,65(12) :1907. 被引量:1
  • 9庞灵恩,管得宁,张扬,吴家勇,徐运.帕金森病轻度认知障碍的相关因素及对生活质量的影响[J].中国实用神经疾病杂志,2014,17(12):59-61. 被引量:3
  • 10Domellof ME, Forsgren L, Elgh E. Persistence of associa-tions between cognitive impairment and motor dysfunctionin the early phase of Parkinson's disease [ J ]. J Neurol,2013,260(9) :2228. 被引量:1

二级参考文献26

共引文献15

同被引文献74

  • 1郭起浩,洪震,吕传真,于欢,丁玎.Mattis痴呆评定量表(中文版)的效度分析[J].中国临床心理学杂志,2004,12(3):237-238. 被引量:16
  • 2杨志杰,谢桂清,李美琳,赵友文.帕金森病人智能损害与临床的关系──采用心理测查量表及正常对照研究[J].北京医科大学学报,1994,26(6):467-469. 被引量:3
  • 3张振馨,.帕金森病的诊断[J].中华神经科杂志,2006,39(6):408-409. 被引量:539
  • 4Aarsland D,Bronnick L,Larsen JP,et al.Cognitive impairment in incident,untreated Parkinson disease:the Norwegian Park West study.Neurology [J].2009,72:1121-1126. 被引量:1
  • 5Williams-Gray CH,Foltynie T,Brayne CE,et al.Evolution of cognitive dysfunction in an incident Parkinson's disease cohort [J].Brain, 2007,130:1787-1798. 被引量:1
  • 6Aarsland D,Andersen K,Larsen JP,et al.Prevalence and char- acteristics of dementia in Parkinson disease: an 8-yesr prospe- ctive study [J].Arch Neurol,2003,60:387-392. 被引量:1
  • 7Hely MA,Reid WC,,Adena MA,et al.The Sydney multicenter study of Parkinson's disease:the inevitability of dementia at 20 years[J].Mov Disord,2008,23 : 837-844. 被引量:1
  • 8Hughes AJ,Daniel SE,Kilford L,etal.Accuracy of clinlcal diagnos- is of idiopathic Parkinson's disease: a clinic-pathological study of 100 cases [J]J Neurol Neurosurg Psychiatry,1992,55:181-184. 被引量:1
  • 9Muslimovic D,Post B,Speelman JD,etal.Cognitive profile of patients with newly diagnosed Parkinson disease[J].Neurology, 2005,65 (8) : 1239-1245. 被引量:1
  • 10Aarsland D,Zaccai J,Brayne C,etal.A systematic review of prevalence studies of dementia in Parkinson's disease[J].Mov Disord, 2005,20 : 1255 - 1263. 被引量:1

引证文献9

二级引证文献13

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈