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河南省人民医院2011-2013年住院病人特殊使用级抗菌药物应用分析 预览 被引量:3

Utilization of specialized antibacterial drugs in inpatients of People's Hospital of Henan Province from 2011 to 2013
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摘要 目的:调查河南省人民医院住院病人特殊使用级抗菌药物(specialized antibacterial drugs,SADs)的临床使用情况,为临床合理应用SADs提供参考。方法:对2011-2013年SADs的种类、用药金额、用药频度(DDDs)、日均用药金额(DDC)进行回顾性分析,并分析主要病原菌对不同SADs的敏感率变化。结果:本院2011-2013年SADs的DDDs总体呈上升趋势,最常用的是β-内酰胺类、碳青霉烯类及糖肽类药物。大肠杆菌、铜绿假单胞菌和肺炎克雷伯菌对多种SADs的敏感率呈现小幅波动,金黄色葡萄球菌则始终对利奈唑胺、万古霉素、替考拉宁保持高度敏感,而鲍曼不动杆菌对多种SADs的敏感率均〈20%。结论:需要进一步规范医院SADs的选择和使用,使其更加安全、有效、经济和合理。 Objective: To investigate the application of specialized antibacterial drugs (SADs) in inpatients of People's Hospital of Henan Province from 2011 to 2013, so as to provide reference for rational use of SADs. Methods: The varieties, consumption sum,the frequency of medication(DDDs) and daily drug cost(DDC) of SADs used in inpatient pharmacy of the hospital from 2011 to 2013 were retrospectively analyzed. The changes in sensitive rates for main detected bacteria to different SADs were also investigated. Results: The DDDs of SADs generally increased from 2011 to 2013. The most frequently used SADs in the hospital were β-lactams, carbopenerns and glycopeptides. The sensitive rates of Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae to various SADs showed a slight fluctuation,the sensitive rate of Staphylococcus aureus to linezolid, vancomycin and teicoplanin remained high, however, the sensitivity rate of Acinetobacter baumannii to various SADs was less than 20%. Conclusion: The selection and application of SADs need to be further standardized in the hospital,so as to ensure safe, effective, rational and economic application of SADs.
作者 王丽 范国荣 王山梅 李轶 张亚平 WANG Li ,FAN GuoRong ,WANG ShanMei ,LI Yi ,ZHANG YaPing (1. Department of Pharmacy, People's Hospital of Henan Province, Zhengzhou 450000, China; 2. Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai Key Laboratory for Pharmaceutical (Chinese Materia Medica) Metabolite Research, Shanghai 200433, China ; 3. Department of Clinical Laboratory, People's Hospital of Henan Province, Zhengzhou 450000, China)
出处 《药学服务与研究》 CAS CSCD 2014年第6期439-442,共4页 Pharmaceutical Care and Research
关键词 抗生素类 特殊使用级 药物利用评审 用药频度 日均用药金额 antibacterial drugs, specialized drug utilization review frequency of medication daily drug cost
作者简介 王丽(女),硕士,药士.E—mail:xggwan@163.com 通信作者:范国荣,E—mail:guorfan@163.com
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