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胸腔镜肺叶切除术与开胸肺叶切除术治疗临床Ⅰa期非小细胞肺癌对比研究 预览 被引量:10

Comparative study on thoracoscope lobectomy and thoracotomy lobectomy for treating stage Ⅰa non-small cell lung cancer
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摘要 目的观察胸腔镜肺叶切除术和传统开胸肺叶切除术治疗Ⅰa期非小细胞肺癌(NSCLC)的疗效及安全性。方法选择2008年1月至2012年1月在北京大学深圳医院行手术治疗的Ⅰa期NSCLC患者160例,其中80例行胸腔镜肺叶切除术(胸腔镜组),80例行开胸肺叶切除术(开胸组);比较2组患者的手术时间、切口长度、术中出血量、术后引流量、引流管放置时间、淋巴结清扫个数、住院时间、术后并发症及3 a生存率。结果胸腔镜组患者的手术时间、住院时间及切口长度显著短于开胸组(P〈0.05),术中出血量、术后引流量显著少于对照组(P〈0.05);2组患者的引流管留置时间及淋巴结清扫数目比较差异均无统计学意义(P〉0.05)。胸腔镜组和开胸组患者并发症发生率分别为5.0%、11.3%,胸腔镜组患者并发症发生率显著低于开胸组(P〈0.05)。2组患者1、2、3 a生存率比较差异均无统计学意义(P〉0.05)。结论胸腔镜肺叶切除术治疗Ⅰa期NSCLC安全可靠,具有创伤小、手术时间短、术中出血量少、并发症发生率低及住院时间短等优点。 Objective To observe the effect and safety of thoracoscope lobectomy and traditional thoracotomy lobectomy for treating stage Ⅰa non-small cell lung cancer( NSCLC). Methods A total of 160 patients with stage Ia NSCLC who underwent surgery in Shenzhen Hospital Affiliated to Peking University from January 2008 to January 2012 were selected. Eighty patients in thoracoscope group were treated with thoracoscope lobectomy,while eighty patients in thoracotomy group were treated with thoracotomy lobectomy. The operation time,incisional length,intraoperative bleeding volume,postoperative drainage volume,drainage tube placement time,the number of lymph node dissection,hospitalization time,postoperative complications and3-year survival rate were compared between the two groups. Results The operation time,hospitalization time and incisional length in thoracoscope group were significantly shorter than those in thoracotomy group( P〈0. 05). The intraoperative bleeding volume and postoperative drainage volume in thoracoscope group were significantly less than those in thoracotomy group( P〈0. 05). There was no significant difference in the drainage tube placement time and the number of lymph node dissection between the two groups( P〉0. 05). The incidence rate of complication in thoracoscope group and thoracotomy group was 5. 0%and 11. 3% respectively,the incidence rate of complication in thoracoscope group was significantly lower than that in thoracotomy group( P〈0. 05). There was no significant difference in the 1,2 and 3-year survival rate between the two groups( P〉0. 05). Conclusion Thoracoscope lobectomy for treating stage Ⅰa NSCLC is safe and dependable with little operation wound,short operation time,less intraoperative bleeding volume,few complications and short hospitalization time.
作者 牟志民 张海 毛广显 谢远财 彭旭兴 乌达 MOU Zhi-min, ZHANG Hai, MAO Guang-xian, XIE Yuan-cai, PENG Xu-xing, WU Da (Department of Thoracic Surgery, Shenzhen Hospital Affiliated to Peking University, Shenzhen 518036, Guangdong Province, China)
出处 《新乡医学院学报》 CAS 2015年第2期149-151,共3页 Journal of Xinxiang Medical College
基金 深圳市科技计划项目(编号:JCYJ20140415162338820) 深圳市医疗卫生科研项目(编号:201302068)
关键词 胸腔镜 开胸手术 肺叶切除 非小细胞肺癌 thoracoscope thoracotomy lobectomy non-small cell lung cancer
作者简介 牟志民(1963-),男,广西柳州人,学士,副主任医师,研究方向为胸外科疾病。 通信作者:乌达(1963-),男,内蒙古通辽人,硕士,主任医师,从事胸外科临床诊治工作;E-mail:wudal963@163.com。
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