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中医综合疗法治疗前列腺癌骨转移的临床观察 被引量:8

Clinical Effect of Comprehensive Chinese Medical Therapy on Osseous Metastasis of Prostatic Carcinoma
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摘要 目的:观察中药联合针灸治疗晚期前列腺癌骨转移的临床疗效。方法:将68例晚期前列腺癌骨转移患者随机分为治疗组(34例)和对照组(34例)。所有患者均给予全雄激素阻断治疗,即手术/药物去势+类固醇类抗雄激素药物治疗,治疗组在上述基础治疗的同时给予加味耆凌骨转方加减结合针灸治疗,对照组采用现代化学止痛药物治疗。治疗周期为3个月。评价两组患者的临床疗效;检测并比较两组患者的血清碱性磷酸酶(ALP)水平;采用数字评价量表(NRS)评定患者的骨转移疼痛情况;采用欧洲癌症治疗研究组织(EORTC)制定的生存质量调查表(EORTC-QLQ)中c30和PR25子量表评定患者的生存质量。结果:①临床疗效:治疗组和对照组的总有效率分别为26.5%和23.5%,两组临床疗效比较,差异无统计学意义(P〉0.05)。②ALP水平:治疗后,对照组患者的血清ALP水平明显升高(P〈0.05),且显著高于治疗组(P〈0.05)。③NRS评分:治疗后,两组患者的NRS评分较治疗前均显著降低(P〈0.05),而两组患者的NRS评分比较,其差异则无统计学意义(P〉0.05)。④EORTC-QLQC30子量表评分:治疗后,治疗组患者的疲乏、疼痛维度评分较治疗前显著降低(P〈0.05),经济困难、躯体功能、情绪功能、总体健康状况维度评分显著升高(P〈0.05);对照组患者的疼痛维度评分显著降低(P〈0.05),经济困难、情绪功能、总体健康状况维度评分显著升高(P〈0.05);且治疗组患者的疲乏、恶心呕吐、失眠维度评分显著低于对照组(P〈0.05),躯体功能、总体健康状况维度评分高于对照组(P〈0.05)。⑤EORTC-QLQPR25子量表评分:治疗后,两组患者的排尿症状维度评分均显著降低(P〈0.05),治疗相关症状维度评分显著升高(P〈0.05),且治疗组� Objective : To observe the effect of Chinese medicine combined with acupuncture in treating osseous metastasis of advanced prostatic carcinoma. Methods : A total of 68 patients with osseous metastasis of advanced prostatic carcinoma were randomly divided into treatment group (34 cases) and control group (34 cases). All the patients were treated with maximal androgen blockade, and the treatment group was treated with "Qiling Guzhuan Formula" combined with acupuncture and the control group was treated with analgesic drugs on the basis of above treatment. The treatment course was 3 months. The clinical effect was evaluated; the level of alkaline phosphatase (ALP) was detected; the pain of osseous metastasis was assessed by numerical rating scale (NRS) ; the quality of life was evaluated by Quality of Life Questionnaire-C30 and -PR25 of European Organization for Research and Treatment of Cancer (EORTC). Results: ①Clinical effect: The total effective rates of the treatment group and control group were 26.5% and 23.5% respectively, with no statistical difference between the two groups ( P 〉 0.05 ). ②The level of ALP : After treatment, the level of ALP of the control group was obviously increased ( P 〈 0.05 ) and was higher than that of the treatment group (P 〈 0.05 ). ③NRS scores : After treatment, the NRS scores of both groups were significantly decreased ( P 〈 0.05 ) , with no statistical difference between the two groups (P 〉 0.05 ). ④EORTC- QLQ c30 scores: After treatment, the scores of fatigue and pain dimensions were decreased ( P 〈 0.05 ), and the scores of economic difficulty, somatic function, emotional function and total healthy condition dimensions were increased (P 〈 0.05 ) in the treatment group ; the scores of pain dimension were decreased ( P 〈 0.05 ), and the scores of economic difficulty, emotional function and total healthy condition dimensions were increased ( P 〈 0.05 ) in the control group ; the scor
作者 郁超 曹宏文 何晓锋 冯懿赓 孙鹏 陈磊 YU Chao CAO Hong-wen HE Xiao-feng FENG Yi-geng SUN Peng CHEN Lei ( Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine)
出处 《上海中医药大学学报》 CAS 2015年第2期26-30,共5页 Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai
基金 上海市卫生局中西医结合重点专科建设项目 上海市“杏林新星”人才培养计划项目(ZYSNXD011-RC-XLXX.20130029) 上海市名中医周智恒工作室建设项目(ZYSNXD.CC-MZY011) 上海市科委科研基金资助项目(13401901702)
关键词 前列腺癌 骨转移 中药 针灸 生存质量 prostatic carcinoma osseous metastasis traditional Chinese medicine acupuncture and moxibustion quality of life
作者简介 郁超,男,博士,副主任医师,主要从事中医、中西医结合泌尿男科临床研究 [通讯作者]陈磊,主任医师,硕士生导师;E-mail:joe8989@163.com
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