Objective To investigate clinical efficacy of combine alprostadil sequential therapy with Danshen driping piUs in treatment of elderly patients with diabetic nephropathy. Methods 80 cases of eider patients with diabetic nephropathywere randomly divided into control group and observation group, 40 cases in each group. Patients in control group were given conventional treatment ＋Danshen driping pills for 4 weeks, and patients in observation group were given alprostadil sequential therapy（alprostadil injection for 2 weeks＋beraprost sodium tablets for 2 weeks） based on conventional treatment. The total protein, thromboxane B2,24 h urinary albumin （UMA） and urinary 6-keto-prostaglandin F1α levels and renal blood flow of two groups were observed. Results After treatment, UMA and total protein levels of two groups were significantly reduced, and UMA and total protein levels of observation group were significantly lower than those of control group （P〈0.05）; kidney artery, segmental arteries and leaves artery resistance index （RI） of two groups were significantly decreased, and RI of observation group was significantly lower than that of control group （P〈0.05）; 6-keto- PGF1α levels of two groups were significantly improved, and 6-keto-PGF1α of observation group was significantly higher than that of control group （P〈0.05）; thromboxane B2 levels of two groups were significantly increased,and thromboxane B2 level of observation group was significantly lower than that of control group （P〈0.05）. Conclusion Combine alprostadil sequential therapy with Danshen driping pills can effectively reduce the urinary protein level and improve hemodynamic of elderly diabetic nephropathy.
Journal Of Tropical Medicine
beraprost sodium tablets