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幽门螺杆菌感染与自身免疫性甲状腺炎的相关性研究 被引量:15

Correlation between Helicobacter py lori infections and autoimmune thyroiditis
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摘要 目的:探讨幽门螺杆菌感染与自身免疫性甲状腺炎的相关性,为自身免疫性甲状腺炎的相关治疗提供参考。方法选取2011年7月-2013年7月收治的125例自身免疫性甲状腺炎患者为试验组,另选取125名健康人群作为对照组;运用免疫酶法分别对两组进行甲状腺球蛋白抗体(TGAb)和抗甲状腺过氧化物酶抗体(TPOAb)的测定,并通过ELISA法对幽门螺杆菌IgG抗体和IgA抗体进行检测;根据检测结果,在幽门螺杆菌IgG抗体阳性的甲状腺炎患者中随机抽选50例患者并将其等分为两组,治疗组予以抗幽门螺杆菌治疗,观察组不予以抗幽门螺杆菌治疗,在完成治疗5个月后,再测定其TGAb和TPOAb滴度并与其治疗前数据进行对比。结果试验组幽门螺杆菌感染阳性率、Ig G阳性率、Ig A阳性率分别为78.4%、66.4%、69.6%,对照组分别为41.6%、32.8%、39.2%,两组比较差异均有统计学意义(P<0.05);治疗组在进行抗幽门螺杆菌治疗后,其TGAb和TPOAb的滴度对比治疗前均有明显下降(P<0.05),而观察组则保持不变。结论幽门螺杆菌感染与自身免疫性甲状腺炎相关,抗幽门螺杆菌治疗是治疗自身免疫性甲状腺炎的有效方法之一。 OBJECTIVE To explore the correlation between the Helicobacter pylori infections and the autoimmune thyroiditis so as to provide guidance for treatment of the autoimmune thyroiditis .METHODS A total of 125 patients with autoimmune thyroiditis who were treated from Jul 2011 to Jul 2013 were chosen as the experimental group , and 125 healthy people were assigned as the control group .The thyroglobulin antibody (TGAb) and anti‐thyroid peroxidase antibodies (TPOAb) were determined by means of immune enzymatic method;the IgG and IgA anti‐bodies of the H .pylori were detected by using ELISA .Totally 50 thyroiditis patients who were tested positive for IgG were randomly extracted and evenly divided into two groups :the treatment group was treated with the anti‐H .pylori therapy ,while the observation group was not given the anti‐H .pylori therapy ,and the TGAb and TPOAb titers were measured after the treatment for 5 months and were compared with those before the treatment . RESULTS The positive rate of H .pylori infection was 78 .4% in the experimental group ,41 .6% in the control group;the positive rate of IgG was 66 .4% in the experimental group ,32 .8% in the control group;the positive rate of IgA was 69 .6% in the experimental group ,39 .2% in the control group ,there was significant difference between the two groups (P〈0 .05) .The TGAb and TPOAb titers of the treatment group were significantly re‐duced after the anti‐H .pylori therapy as compared with those before the treatment (P〈0 .05) ,while they re‐mained unchanged in the observation group .CONCLUSION The H .pylori infection is associated with the autoim‐mune thyroiditis ,and the anti‐H .pylori therapy is an effective way to treat the autoimmune thyroiditis .
作者 汪茂荣 姚平 陈碧玲 WANG Mao-rong, YAO Ping, CHEN Bi-ling (Affiliated Hospital of Hubei Institute for Nationalities, Enshi, Hubei 445000, China)
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2015年第9期1984-1986,共3页 Chinese Journal of Nosocomiology
基金 湖北省民宗委基金资助项目(HBMW2012028)
关键词 幽门螺杆菌 自身免疫性甲状腺炎 甲状腺球蛋白抗体 抗甲状腺过氧化物酶抗体 Helicobacter pylori Autoimmune thyroiditis Thyroglobulin antibody Anti-thyroid peroxidase anti-body
作者简介 通信作者:姚平,E-mail:yaoping0564@163.com
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参考文献6

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