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α-硫辛酸联合常规治疗对早期糖尿病肾病患者血清学指标的影响 预览 被引量:9

Effect of α-lipoic acid combined with conventional therapy on serum markers of early diabetic nephropathy patients
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摘要 目的:研究α-硫辛酸联合常规治疗对早期糖尿病肾病患者血清学指标的影响。方法:选择在本院住院治疗的早期糖尿病肾病患者进行研究,随机分为两组,硫辛酸组接受0t硫辛酸联合常规药物治疗,常规组接受常规药物治疗,比较两组患者的肾功能指标、氧化应激指标、足细胞损伤程度、线粒体融合和分裂蛋白含量。结果:(1)肾功能和氧化应激指标:硫辛酸组的血清胱抑素C(CysC)、视黄醇结合蛋白(RBP)、8-羟基脱氧鸟嘌呤核苷(8-OHdG)、硝基酪氨酸(NT)、丙二醛(MDA)、F2-异前列腺素类化合物(F2-aisoprostanes)含量呈降低趋势,差异均有统计学意义(P〈0.05);(2)足细胞损伤指标:硫辛酸组的血清Nephrin、Podocin、足细胞结蛋白(Desmin)、CD2相关蛋白(CD2AP)含量呈明显升高趋势,差异均有统计学意义(P〈0.05);(3)线粒体指标:硫辛酸组的血清线粒体融合蛋白1(Mfs1)、线粒体融合蛋白2(Mrs2)、视神经萎缩蛋白1(Opal)含量明显升高,分裂蛋白1(Fisl)、线粒体分裂因子(Mff)、神经节苷脂诱导的分化蛋白1(GDAP1)含量明显减低,差异均有统计学意义(P〈0.05)。结论:α-硫辛酸联合常规治疗有助于改善肾功能、缓解氧化应激、保护足细胞结构和线粒体功能,是治疗早期糖尿病肾病的理想方式。 Objective To explore the effect of α-lipoic acid combined with conventional therapy on serum markers of early diabetic nephropathy patients. Methods: Patients with early diabetic nephropathy treated in our hospital were enrolled and randomly divided into two groups. Lipoic acid group received α- lipoic acid combined with conventional drug therapy~ conven- tional group received conventional drug therapy. Then renal function, oxidative stress, podocyte injury degree, mitoehondrial fusion and fission protein contents of both groups were compared. Results: (1) Renal function and oxidative stress indicators; serum CysC, RBP, 8-OHdG, NT, MDA and F2-aisoprostanes contents of lipoic acid group showed a significant decreasing trend; (2) podocyte injury indicators: serum Nephrin, Podocin, Desmin and CD2AP contents of lipoic acid group showed a significantly increasing trend; (3) Mitochondrial indicators: serum Mrs1, Mfs2 and Opal contents of lipoic acid group signifi- cantly increased; Fisl, Mff and GDAP1 contents significantly decreased. Conclusiom α-lipoic acid combining with conventional therapy can help to improve renal function, relieve oxidative stress and protect podocyte structure as well as mitochondrial functiom it's an ideal treatment for early diabetic nephropathy.
作者 靳新东 刘向东 牛喜平 JIN Xin-dong , LIU Xiang-dong , NIU Xi-ping(1. Department of Cardiology, Nephrology, Luohe Hospital of Chinese Medicine, Luohe City, Henan Province, 462000 ; 2. Department of Nephrology , the First Affiliated Hospital of Xinxiang Medical University, Xinxiang City, Henan Province, 453100)
出处 《海南医学院学报》 CAS 2015年第10期1358-1360,1364共4页 Journal of Hainan Medical College
基金 河南省自然科学研究计划项目(201310471055)
关键词 糖尿病肾病 Α-硫辛酸 氧化应激 足细胞 线粒体 Diabetic nephropathy α-lipoic acid Oxidative stress Podocytes Mitochondria
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