期刊文献+

振源胶囊联合小剂量劳拉西泮治疗老年慢性心力衰竭伴焦虑症状的临床观察 预览 被引量:10

Clinical efficiency of Zhenyuan capsule combined with small-dose lorazepam in treatment of elderly chronic heart failure patients with anxiety symptoms
在线阅读 下载PDF
分享 导出
摘要 目的:探讨振源胶囊联合劳拉西泮治疗老年慢性心力衰竭(CHF)伴发焦虑症状患者的有效性和安全性。方法选择2013年1月至2015年2月在北京老年医院门诊及住院收治的315例≥60岁的CHF患者,应用汉密尔顿焦虑量表(HAMA)评价,从中筛选出并发焦虑症状的患者81例,随机分成对照组40例和治疗组41例。两组均按心力衰竭指南给予正规药物治疗、心理干预、康复训练,对照组口服劳拉西泮抗焦虑治疗,治疗组口服劳拉西泮+振源胶囊,观察时间为4周。比较两组治疗前后的心功能分级、HAMA评分、焦虑自评量表(SAS)评分,左室射血分数(LVEF)、血浆氨基端B型利钠肽原(NT-proBNP)的变化。结果治疗组患者心功能分级、HAMA评分、SAS评分的改善均优于对照组,差异有统计学意义(P<0.05);两组患者LVEF、NT-proBNP均较治疗前好转,治疗组好转更明显,两组比较差异无统计学意义(P>0.05)。结论振源胶囊联合劳拉西泮能显著提高CHF伴发焦虑症状患者的临床疗效,不良反应少,依从性好,优于单用劳拉西泮治疗。 ObjectiveTo determine the efficiency and safety of combined treatment of Zhenyuan capsule with lorazepam for anxiety symptoms in the elderly patients with chronic heart failure (CHF).Methods Hamilton Anxiety Scale (HAMA) was employed to assess 315 CHF patients (≥60 years old) admitted in our department from January 2013 to February 2015. Eighty-one of them with anxiety symptoms were screened out and then randomly divided into 2 groups, lorazepam alone group (control group,n=40) and Zhenyuan capsule combined with lorazepam group (treatment group,n=41). Besides these, conventional drug treatment, psychological intervention and rehabilitation training were given to both groups. In 4 weeks later, they were compared by scores of heart functions, HAMA scores, Self-rating Anxiety Scale (SAS) score, left ventricular ejection fraction (LVEF), and serum level of N-terminal B-type natriuretic peptide (NT-proBNP). Results The treatment group had better heart function, HAMA score and SAS score than the control group (P〈0.05). LVEF and NT-proBNP level were both improved in the 2 groups, with more obviously in treatment group, but there was no significant difference between the 2 groups (P〉0.05).Conclusion Zhenyuan capsule combined with lorazepam improves the curative effect on anxiety symptoms in elderly CHF patients, and has less adverse reaction, good compliance and better efficiency than lorazepam alone.
作者 陈晓丽 罗智 魏立和 CHEN Xiao-Li, LUO Zhi, WEI Li-He (1Department of Cardiology, 2Department of Mental Health, Beijing Geriatric Hospital, Beijing 100095, China)
出处 《中华老年多器官疾病杂志》 2015年第8期602-606,共5页 Chinrse journal of Multiple Organ Diseases in the Elderly
基金 北京市中医管理局基金学术创新项目(JJ2014-19)
关键词 振源胶囊 劳拉西泮 焦虑 心力衰竭 Zhenyuan capsule lorazepam anxiety heart failure
作者简介 通信作者:罗智,E-mail:13501228471@139.com
  • 相关文献

参考文献16

  • 1刘萍萍,张健,杨跃进,张宇辉,黄晓红,吕蓉.心力衰竭病人焦虑抑郁调查研究[J].中国循环杂志,2007,22(4):285-288. 被引量:45
  • 2胡大一,于欣主编..双心医学[M].武汉:华中科技大学出版社,2008:135.
  • 3张作记.行为医学量表手册[M].济宁:中国行为医学科学杂志社,2001:124-132. 被引量:50
  • 4张明园.精神科评定量表手册[M]第2版[M].长沙:湖南科学技术出版社,1998.35-42. 被引量:278
  • 5陈明哲..心脏病学[M],1999.
  • 6沈渔邮.精神病学[M].第5版.北京:人民卫生出版社,2009. 被引量:113
  • 7中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014(2):98-122. 被引量:2229
  • 8Alvarez MS, Olmos JJ, Pisa H. Heart failure and depression. A psychosocial perspective[J]. Vertex, 2012, 23(106): 439-445. 被引量:1
  • 9Watson K, Summers KM. Depression in patients with heart failure: clinical implications and management[J]. Pharmacotherapy, 2009, 29(1): 49-63. 被引量:1
  • 10Jiang W, Alexander J, Christopher E, et al. Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure[J]. Arch Intern Med, 2001, 161(15): 1849-1856. 被引量:1

二级参考文献170

共引文献2730

同被引文献78

引证文献10

二级引证文献17

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈