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南通市健康人群流行性乙型脑炎抗体水平及其影响因素

Analysis on Japanese encephalitis antibody level and influencing factors among healthy population in Nantong City
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摘要 目的探讨南通市健康人群流行性乙型脑炎(乙脑)抗体水平及其影响因素,评价人群乙脑免疫屏障,为制定乙脑预防控制策略提供依据。方法采用蚀斑减少中和试验对从如皋和海安两个监测点采集的736份血清标本进行乙脑抗体检测。结果乙脑抗体总的阳性率为71.60%,GMT为1∶16.78。如皋市抗体阳性率高于海安县(χ2=11.54,P〈0.01),两地区均有随年龄的增加抗体水平增长的趋势。多因素logistic分析发现:免疫史、隐性感染、性别与乙脑抗体阳性有关。结论南通市2岁以上人群乙脑抗体有保护作用,但〈1岁的婴儿抗体水平较低,应加强该年龄段人群的保护。 [Objective]To understand the Japanese encephalitis(JE) antibody level among healthy population in Nantong City,analyze the influencing factors,evaluate the immune barrier of JE in population,and provide the basis for developing the prevention and control strategy of JE. [Methods]736 serum specimens collected from two monitoring points of Rugao City and Haian County were detected for the JE antibody by plaque reduction neutralization test. [Results]The total positive rate of JE antibody was 71.60%,and GMT was 1 ∶16.78. The l positive rate of JE antibody in Rugao City was higher than that in Haian County(χ2=11.54,P〈0.01),and the antibody level in two areas increased with increasing age.The multiple logistic regression analysis showed that positive rate was related to immunization history,subclinical infection and sex.[Conclusion]The JE antibody can exert a protective effect on persons over 2 years old in Nantong City. However,JE antibody level among children below 1 year old is low,and it is necessary to strengthen the protection in this population.
作者 金红梅 王智泉 侯晓燕 张志兰 陆培善 邓秀英 JIN Hong-mei, WANG Zhi-quan, HOU Xiao-yan, ZHANG Zhi-lan, LU Pei-shan, DENG Xiu-ying (Nantong Center for Disease Control and Prevention, Jiangsu, 226007, China)
出处 《职业与健康》 CAS 2015年第20期2805-2807,共3页 Occupation and Health
关键词 流行性乙型脑炎 抗体水平 影响因素 Japanese encephalitis Antibody level Influencing factors
作者简介 金红梅,女,主管医师,主要从事计划免疫工作。 通讯作者:王智泉,Email:wwwwwl118@sina.com
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