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珍菊降压片及其中西药配伍的一般药理学比较研究 认领 被引量:2

Comparative Effects on General Pharmacology of Zhenju Jiangya Tablet and Its Chinese Medicine and Western Medicine Components
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摘要 目的:观察珍菊降压片及其处方中西药组分对中枢神经系统、心血管系统、呼吸系统的影响,探寻中西药配伍增(存)效减毒的实验证据。方法:ICR小鼠随机分为珍菊降压片(ZJT)低、中、高剂量组(280,1 120,4 480 mg·kg^-1),另设相应剂量的珍菊降压片中药部分(ZJTZ)低、中、高剂量组(274,1 095,4 380 mg·kg^-1),珍菊降压片西药部分(ZJTX)低、中、高剂量组(6.2,24.9,99.5 mg·kg^-1),正常组,另设安定组。Beagle犬ZJT低、中、高剂量组(60,240,960 mg·kg^-1),另设相应剂量的ZJTZ低、中、高剂量组(58.7,235,939 mg·kg^-1),ZJTX低、中、高剂量组(1.3,5.3,21.3 mg·kg^-1),正常组。给ICR小鼠灌服,或给Beagle犬吞服珍菊降压片及其中药或西药部分,观察小鼠给药后自发活动状况以及协同戊巴比妥钠阈下催眠剂量对催眠的影响,记录和比较Beagle犬在给药前,给药后0.5,1,2,4,8,24 h的收缩压,舒张压,心率,PR间期,QRS波群,QT间期,T波形态,心律,呼吸频率和呼吸深度变化。结果:与正常组比较,ZJT灌胃给ICR小鼠280,1 120,4 480 mg·kg^-1,受试动物自发活动下降,与戊巴比妥钠阈下催眠剂量有协同催眠作用,可缩短睡眠潜伏期,延长睡眠时间(P〈0.05,P〈0.01);吞服给Beagle犬960 mg·kg^-1,受试动物收缩压、心率、呼吸频率和呼吸深度下降,其中血压下降起始时间为1 h,作用持续时间24 h。拆方研究结果显示,ZJT高剂量口服给药产生的收缩压、心率和呼吸频率和呼吸深度下降,以及显著的镇静作用,主要源于组方中的西药部分,给予ZJT,可显著增强降压活性,延长降压时间,阻断PR间期延长(P〈0.05,P〈0.01)。结论:ZJT高剂量口服给药,可使受试动物收缩压下降,其程度与剂量呈正相关,但同时对心率和呼吸有一定的抑制作用。此外,ZJT具有显著的镇静作用。ZJT的上述作用主要源于组方中的西药部分,加入中药部分,可增强降� Objective: To study the effect of Zhenju Jiangya tablet( ZJT) and its Chinese medicine and western medicine components on central nervous system,cardiovascular system,and respiratory system,and then to compare and search for the efficacy of synergism and attenuation. Method: ICR mice were randomly divided into ZJT low-dose,middle-dose and high-dose groups( 280,1 120,4 480 mg·kg^-1),ZJT Chinese medicine part( ZJTZ) low-lose,middle-dose and high-dose groups( 274,1 095,4 380 mg·kg^-1),ZJT western medicine part( ZJTX) low-lose,middle-dose and high-dose groups( 6. 2,24. 9,99. 5 mg·kg^-1),normal group,and another diazepam group. Beagle dogs were divided into ZJT low-dose,middle-dose and high-dose groups( 60,240,960mg·kg^-1),ZJTZ low-lose,middle-dose and high-dose groups( 58. 7,235,939 mg·kg^-1),ZJTX low-lose,middle-dose and high-dose groups( 1. 3,5. 3,21. 3 mg·kg^-1),and normal group. ZJT and its traditional Chinese medicine or western medicine part were respectively ig administered to ICR mice or orally administered to Beagle dogs. Spontaneous activity after the treatment in mice,and effect of synergistic subthreshold hypnotic dose of sodium pentobarbital on hypnosis were observed. Changes of systolic pressure,diastolic blood pressure,heart rate,PR interval,QRS complex,QT interval,T wave form,rhythm of heart,breathing rate and breathing depth were recorded and compared before and 0. 5,1,2,4,8,24 h after treatment in Beagle dogs. Result: Compared with the normal group,spontaneous activity was reduced in tested mice at doses of 280,1 120,4 480 mg·kg^-1with ig ZJT,with synergistic hypnotic effect with subthreshold hypnotic dose of sodium pentobarbital,shortened sleep latency and prolonged sleep time( P〈 0. 05,P 〈0. 01). The oral administration at dose of 960 mg·kg^-1 in Beagle dogs reduced systolic pressure,heart rate,breathing rate and breathing depth in tested animals,where the blood pressure began to decrease at 1 h and lasted for 24 h. Prescription studies sho
作者 谢家骏 乔正东 成苗 阮晓东 王建新 XIE Jia-jun, QIAO Zheng-dong, CHENG Miao, RUAN Xiao-dong, WANG Jian-xin ( 1. Center of Drug Safety Evaluation and Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 2. Shanghai Pudong Hospital, Shanghai 201399, China; 3. Shanghai Institute of Chinese Materia Medica, Shanghai 201203, China; 4. School of Pharmacy, Fudan University, Shanghai 201203, China)
出处 《中国实验方剂学杂志》 CAS CSCD 北大核心 2015年第23期110-116,共7页 China Journal of Experimental Traditional Medical Formulae
基金 国家“重大新药创制”科技重大专项(2011ZX09301-009) 上海市科委中药现代化专项(04DZ19854)
关键词 珍菊降压片 一般药理学 自发活性 收缩压 心率 PR间期 呼吸频率 呼吸深度 Zhenju Jiangya tablets general pharmacology spontaneous activity systolic blood pressure heart rate PR interval breathing rate breathing depth
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