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血清高敏C反应蛋白和氧化型低密度脂蛋白自身IgG抗体可作为急性冠脉综合征的预后指标 被引量:5

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摘要 目的探讨急性冠脉综合征(ACS)患者血清高敏C反应蛋白(hs CRP)和氧化型低密度脂蛋白自身IgG(ox LDL-IgG)水平变化及其与ACS患者预后的相关性。方法分别采用夹心ELISA和间接ELISA检测79例发病6 h以内的ACS患者和40例对照组血清hs CRP与ox LDL-IgG的水平,研究二者在ACS早期的变化规律。对ACS患者随访2年,记录心血管不良事件的发生例数,探讨hs CRP和ox LDL-IgG与ACS患者预后的相关性。结果与对照组相比,ACS组血清hs CRP水平显著升高,ACS组血清ox LDL-IgG反应指数也明显升高。血清hs CRP与ox LDL-IgG水平高的ACS患者2年内不良事件的发生率明显高于血清hs CRP与ox LDL-IgG水平低的患者。结论 ACS患者血清hs CRP与ox LDL-IgG的水平可作为判定ACS患者预后的指标。
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2015年第12期1686-1689,共4页 Journal of Cellular and Molecular Immunology
基金 西安市卫生局科技计划项目(J2010C01)
作者简介 于少娟(1974-),女,内蒙古赤峰人,副主任医师,博士研究生Tel:029-87630812;E-mail:ysj029@163.com. 通讯作者,程曼丽,E-maiJ:cml591212@163.com 通讯作者,孙超峰,E-mail:cfsunl@126.com;
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