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右美托咪定联合持续气道正压通气对老年开胸手术患者肺组织氧化应激及炎症反应影响 被引量:12

Effect of Dexmedetomidine Combined with Continuous Positive Airway Pressure on Oxidative Stress and Inflammatory Responses in Elderly Patients Undergoing Chest Operation
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摘要 目的:探讨右美托咪定联合持续气道正压通气对老年开胸手术患者肺组织氧化应激及炎症反应影响。方法:126例全麻下开胸手术的老年患者随机分为右美托咪定组、正压通气组和联合组,3组患者均行单肺通气的同时给予不同处理。记录不同时点3组患者氧化应激及炎症反应指标变化。结果:与右美托咪定组或正压通气组相比,联合组T2-3时刻血清丙二醛、皮质醇、C-反应蛋白、IL-6和TNF-α浓度均降低(P〈0.05);术后1d,联合组患者肺部并发症发生率低于右美托咪定组和正压通气组(P〈0.05)。结论:右美托咪定联合持续气道正压通气可减轻老年开胸手术单肺通气时肺组织氧化应激和炎症反应,减少术后并发症发生。 Objective:To investigate the effect of dexmedetomidine combined with continuous positive airway pressure on oxidative stress and inflammatory responses in elderly patients undergoing chest operation.Methods:126cases of elderly patients undergoing open chest operation were randomly divided into dexmedetomidine group,positive pressure group and combined group.Three groups of patients were taken one-lung ventilation,and accepted different treatment.The changes of indexes of oxidative stress and inflammation among the three groups at different points were recorded.Results:Compared with dexmedetomidine group or positive pressure group,the concentrations of malondialdehyde,cortisol,C-reactive protein,IL-6and TNF-αin combined group were detected at T2-3 moments(P〈0.05).Postoperative 1d,the pulmonary complication rate was lower than those in dexmedetomidine group and positive pressure group(P〈0.05).Conclusion:Dexmedetomidine combined with continuous positive airway pressure ventilation could effectively reduce the oxidative stress and inflammatory reaction in elderly patients undergoing chest operation during one-lung ventilation,and reduce the postoperative complications.
作者 张继晨 孟瑞霞 韩威利 杜增利 ZHANG Jichen , MENG Ruixia , HAN Weili , DU Zengli(1Dept, of Anesthesia, Xinxiang Central Hospital, Xinxiang 453000, Henan, China 2Jiaozuo Mine Central Hospital, Jiaozuo 454150, Henan, China)
出处 《武汉大学学报:医学版》 CAS 2016年第1期97-100,共4页 Medical Journal of Wuhan University
关键词 开胸术 右美托咪定 持续气道正压通气 氧化应激 炎症反应 Open Chest Surgery Dexmedetomidine Continuous Positive Airway Pressure Oxidative Stress Inflammation
作者简介 张继晨,女,1974,主治医师,主要从事心胸外科麻醉学研究
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