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阻塞性睡眠呼吸暂停低通气综合征并2型糖尿病患者血清肿瘤坏死因子-α和血浆内皮素的变化及意义 被引量:6

The clinical significance and changes of serum tumor necrosis factor and plasma endothelium in patients with OSAHS associated Type 2 diabetes mellites
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摘要 目的:探讨肿瘤坏死因子-α(TNF-α)和血浆内皮素(ET)在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并2型糖尿病(T2DM)病理生理过程中的意义。方法:观察80例OSAHS患者(OSAHS组)、65例OSAHS合并T2DM患者(OSAHS+T2DM组)、20例T2DM患者(T2DM组)、32名健康者(对照组)。采用双抗体夹心酶联免疫吸附法检测上述4组研究对象的血清TNF-α和ET水平,比较OSAHS组与OSAHS+T2DM组患者经持续正压通气(CPAP)或手术治疗3个月后的TNF-α、ET含量的变化。结果:OSAHS+T2DM组血清TNF-α水平高于OSAHS组、T2DM组和对照组(均P〈0.05);OSAHS组和T2DM组血清TNF-α水平高于对照组;OSAHS组和T2DM组之间血清TNF-α水平无差异;4组之间ET水平无显著性差异。在OSAHS组、OSAHS+T2DM两组中,血清TNF-α在治疗前后分别进行比较,差异均有统计学意义(P〈0.05),其中OSAHS+T2DM组治疗前后比较有显著性差异(P〈0.01),而OSAHS组、OSAHS+T2DM两组ET在治疗前后比较均无差异(P〉0.05)。结论:TNF-α可能参与了OSAHS并T2DM的发生发展过程,而ET可能对OSAHS并T2DM的发生发展过程影响不大。 Objective:To investigate the significance of tumor necrosis factor-alpha(TNF-α)and plasma endothelium(ET)in pathophysiologic process of patients with obstructive sleep apnea hypopnea syndrome(OSAHS)with type 2diabetes mellitus(T2DM).Method:All observed subjects were divided into 4groups.A number of 80 patients with OSAHS,65 cases of OSAHS with T2DM patients,20 patients with T2DM,and 32 cases of healthy control group were observed in this study.The serum levels of TNF-αand ET were detected by double antibody sandwich ELISA,the content of TNF-αand ET were compared between OSAHS group and OSAHS +T2DM group.It were also compared before and after treatment of CPAP or surgery.Result:TNF-αlevel is higher in OSAHS+T2DM group than that in the OSAHS group,T2DM group and the control group(P〈0.05);TNF-αlevel in OSAHS group and the T2DM group are higher than that in the control group(P〈0.05),but there was no difference in TNF-αlevel between the OSAHS group and the T2DM group.There was also no difference in ET level of the four groups.There were significant differences of TNF-αbefore and after treatment of CPAP or surgery in OSAHS group and OSAHS+T2DM group(P〈0.05).But there was no significant differences of ET before and after treatment of CPAP or surgery in the OSAHS+T2DM group(P〉0.05).Conclusion:TNF-αmay be involved in the development of OSAHS and T2DM,while ET may have little effect on the occurrence and development of OSAHS and T2DM.
作者 惠培林 贾双保 马薇 赵丽君 王金凤 魏晓泉 周丽雅 戴满科 张文娟 谢宇平 HUI Peilin,JIA Shuangbao,MA Wei,ZHAO Lijun,WANG Jinfeng,WEI Xiaoquan,ZHOU Liya,DAI Manke,ZHANG Wenjuan,XIE Yuping(1.People's Hospital of Gansu Provincial, Sleep Medical Center of Gansu Provincial, Lanzhou, 730000, China 2Department o{ Endocrine,Wushan Country Peoplers Hospital)
出处 《临床耳鼻咽喉头颈外科杂志》 CAS 北大核心 2016年第3期217-219,225共4页 Journal of Clinical Otorhinolaryngology
基金 天水市科技局项目[No:天财建(2014)389号]
关键词 睡眠呼吸暂停低通气综合征 阻塞性 2型糖尿病 肿瘤坏死因子-α 血浆内皮素 sleep apnea hypopnea syndrome obstructive type 2diabetes mellites tumor necrosis factor-alpha plasma endothelium
作者简介 通信作者:谢宇平,E—mail:xyp5894@163.com
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