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广西壮族自治区贵港市〈15岁儿童急性脑炎和脑膜炎症候群监测分析 被引量:3

Syndromic Surveillance of Acute Meningitis and Encephalitis among Children Aged 〈15 Years in Guigang, Guangxi Zhuang Autonomous Region
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摘要 目的了解广西贵港市〈15岁儿童急性脑炎和脑膜炎(Acute Meningitis and Encephalitis,AME)的发病情况、主要病原及分布特征,为疾病防控和临床诊治提供依据。方法对符合监测病例定义的病例进行流行病学个案调查,采集血液和/或脑脊液(Cerebrospinal Fluid,CSF)标本进行流行性乙型脑炎(Japanese Encephalitis,JE)、常见病毒性脑炎病原、细菌学培养和聚合酶链反应(PCR)检测。结果 2007年5月~2012年6月共监测到〈15岁AME病例1 814例,死亡63例;总AME、JE、其他病毒性AME和细菌/真菌性AME年均发病率分别为46.31/10万、2.76/10万、16.58/10万和1.68/10万。病例以病毒感染为主,肠道病毒、腮腺炎病毒和JE病毒为前三位致病原。各种病原病例均为男性多于女性,〈5岁儿童占多数;细菌/真菌感染较病毒感染临床症状重且病死率高;CSF白细胞是鉴别细菌性和病毒性脑炎的独立相关因素。结论 〈15岁儿童AME以病毒性感染更为多见,医疗机构有必要开展常见的致病原检测。 Objective To determine incidence rates, most common pathogens, and epidemiological char- acteristics of acute meningitis and encephalitis (AME) among children, age 〈 15 years. Methods Children who met the case definition were studied, and blood and/or cerebrospinal fluid (CSF) speci- mens were collected from these subjects. Presence of Japanese Encephalitis (JE) and other common vi- ral, bacteriological pathogens was tested through culture and polymerase chain reaction (PCR). Results From May 2007 to June 2012, 1 814 AME cases, age 〈 15 years, were identified; 63 cases died The inci- dence rates of total AME, JE, other viral AME and bacteriab/fungal AME were 46. 31, 2. 76, 16. 58 and 1.68 per 100,000 population, respectively. Viral infection caused most AME cases, and among viral ca- ses, enterovirus, mumps virus, and JE virus were the top three pathogens. AME cases among males were more common than among females; most cases were among children aged 〈 5 years. Bacterial and funsal infections had more severe clinical manifestations and higher fatality rates than viral infections. CSF leuko- cyte count was an independent factor to differentiate viral from bacterial/fungal infection. Conclusions AME among children aged 〈 15 years were mainly caused by viral pathogens. Hospitals should enhance the etiologic testing for common pathogens.
作者 谢艺红 谭毅 吴兴华 闭福银 何德辉 黄小坤 XIE Yi-hong, TAN Yi, WU Xing-hua, et al. (Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning 530028, Guangxi, China)
出处 《中国疫苗和免疫》 北大核心 2016年第1期65-69,共5页 Chinese Journal of Vaccines and Immunization
基金 国家卫生和计划生育委员会和世界卫生组织流行性脑脊髓膜炎和流行性乙型脑炎等疾病监测合作项目(AMES Project) 广西青年基金课题(2011GXNSFB018090)
关键词 急性脑炎和脑膜炎 症候群监测 病原 儿童 Acute Meningitis and Encephalitis Syndrome Surveillance Pathogens Children
作者简介 谢艺红(1978-),女,广西平南县人,广西壮族自治区疾病预防控制中心副主任医师,博士,主要从事传染病预防控制工作。电话:07712518312.E-mail:wallstreetxie@hotmail.com. 通讯作者:吴兴华。电话:07712518319.E-mail:blankwoo@126.com.
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