Reticular fiber staining is one of the classical method for special staining in pathology and has been wildly used in diagnosis and differential diagnosis of various diseases. Pathological diagnosis has been regarded as the golden standard in diagnosis and classification of many tumors, in which reticular fiber staining plays important roles. The changes of reticular fiber have important implications for clinical pathological diagnosis including hematological malignancies, fibro-epithelioma of breast, gastrointestinal mesothelioma, nervous system tumors, etc. However, in the process of reticular fiber staining, there may be some problems such as fiber coloring bad, fibrous degeneration and calcification, etc. This article reviews application of reticular fiber staining and common problems in the process of staining.
China Medical Herald