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缩宫素联合米索前列醇对子宫收缩乏力性产后出血的临床观察 被引量:25

Clinical observation of oxytocin combined with misoprostol for preventing postpartum hemorrhage of uterine contraction
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摘要 目的:探讨缩宫素联合米索前列醇在防治子宫收缩乏力性产后出血的效果,为临床治疗方案的制定提供参考。方法选取行剖宫产分娩的产妇150例,随机分为观察组和对照组各75例。两组产妇均在娩出胎儿后于子宫壁注射缩宫素。对照组在娩出胎盘后应用缩宫素静脉滴注防治产后出血,观察组采用米索前列醇舌下含服防治产后出血。对比两组产妇术后2h的出血量、产后出血的发生率;同时对比两组产妇临床治疗的有效率和不良反应发生率。结果观察组术后2 h出血量为(348.06±218.36) mL,产后出血发生率为2.67%,显著低于对照组相应指标,差异有统计学意义(t=5.25,χ2=12.37,均P<0.05);观察组的显效率为64.00%,总有效率为93.33%,对照组的显效率为37.33%,总有效率为64.00%,观察组的显效率和总有效率均显著高于对照组相应指标,差异有统计学意义(χ2=10.67、19.22,均P<0.05);对照组用药过程中1例出现恶心呕吐,2例出现发热,不良反应发生率为4.00%;观察组用药过程中有5例出现恶心呕吐,3例出现发热,不良反应发生率为10.67%。对照组的不良反应发生率低于观察组,但差异无统计学意义(χ2=2.452,P>0.05)。结论缩宫素联合米索前列醇可显著减少产妇的产后出血量,降低产后出血的发生率,且不良反应少,是防治子宫收缩乏力性产后出血的有效治疗方案。 Objective To investigate the effect of oxytocin combined with misoprostol in the prevention of postpartum hemorrhage of uterine contraction,and to provide reference for clinical treatment.Methods 150 women who underwent cesarean section were randomly divided into observation group and control group,75 cases in each group.The two groups were all in the expulsion of the fetus after injection of oxytocin in the uterine wall.The control group after delivery of the placenta received oxytocin intravenous infusion in the prevention and treatment of postpar-tum hemorrhage,the observation group used misoprostol under the tongue to prevent postpartum hemorrhage.The inci-dence of bleeding and postpartum hemorrhage was compared between the two groups.The effective rate and incidence rate of adverse reactions of the two groups were compared.Results The bleeding volume of the observation group was (348.06 ±218.36) mL,and the incidence rate of postpartum hemorrhage was 2.67%,which were significantly lower than the control group (t=5.25,χ2 =12.37,all P〈0.05).The effective rate of the observation group was 64%,the total effective rate was 93.33%,the total effective rate was significantly higher than that in the control group (χ2 =10.671,9.22,all P〈0.05).1 case of nausea and vomiting occurred in the control group,2 cases had fever,the incidence rate of adverse reactions was 4.00%.5 cases in the observation group had nausea and vomiting,3 cases had fever,the incidence rate of adverse reactions was 10.67%.The incidence of adverse reactions had no significant difference between the two groups.Conclusion Oxytocin combined with misoprostol can significantly reduce the amount of postpartum hemorrhage,reduce the incidence of postpartum hemorrhage,and less adverse reactions,it is the effective treatment for prevention and treatment of uterine contraction fatigue postpartum hemorrhage.
作者 周向群 罗宇婷 Zhou Xiangqun, Luo Yuting( Department of Obstetrics and Gynecology,the Peopled Hospital of Kaihua County,Zhejiang 324300, China)
出处 《中国基层医药》 CAS 2016年第8期1188-1192,共5页 Chinese Journal of Primary Medicine and Pharmacy
关键词 缩宫素 米索前列醇 子宫收缩乏力 产后出血 Oxytocin Misoprostol Uterine contraction fatigue Postpartum hemorrhage
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