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安神定志灵系列方治疗多发性抽动症疗效观察 被引量:9

Efficacy of Anshen Dingzhiling Recipes in Treating Tourette Syndrome
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摘要 目的:观察安神定志灵系列方治疗儿童多发性抽动症的临床疗效。方法:120例抽动症患儿按照随机数字表法分为试验组和对照组,各60例。试验组根据临床辨证服用安神定志灵系列方,对照组口服氟哌啶醇片,从0.05 mg·kg^-1·d^-1开始,每天2次。两组均以2月为1疗程,每2周观察1次,观察2个疗程。运用耶鲁综合抽动严重程度量表(YGTSS)及中医适应证候分级量化标准表记录治疗前后多发性抽动症积分变化情况,统计试验组中医证型变化规律。结果:YGTSS量表显示,试验组临床控制5例(8.3%),显效45例(75%),进步10例(16.7%),无效0例(0%),控显率为83.3%;对照组临床控制7例(11.7%),显效41例(68.3%),进步12例(20%),无效0例(0%),控显率为80%;中医适应证候分级量化标准表显示,试验组临床控制4例(6.7%),显效47例(78.3%),进步9例(15%),无效0例(0%),控显率为85.0%;对照组临床控制6例(10%),显效46例(76.7%),进步8例(13.3%),无效0例(0%),控显率为86.7%;两组治疗前后比较均有显著差异(P〈0.01)。试验组不良反应发生率低于对照组。结论:安神定志灵系列方分期治疗多发性抽动症临床疗效与西药氟哌啶醇作用相当,且不良反应小,值得深入研究。 Objective: To observe the clinical efficacy of Ansheng Dingzhiling recipes in children with Tourette syndrome( TS). Method: The 120 cases of children with TS were randomly divided into experimental group and control group,with 60 cases in each group. Patients in experimental group took Ansheng Dingzhiling recipes according to the clinical syndrome,while patients in control group orally took haloperidol tablets,from the beginning of 0. 05 mg·kg^-1·d^-1,2 times a day. The treatment course was 2 months for both groups,and patients were observed once every two weeks for a total of 2 months. Yale Global Tic Severity Scale( YGTSS) and traditional Chinese medicine( TCM) syndrome grading and classification scale were used to record the changes of TS symptom scores before and after treatment,compare the efficacy and adverse reactions between two groups,and find the rules of TCM syndrome changes in experimental group by statistical method. Result: YGTSS results were as follows,the experimental group: clinical control in 5 cases( 8. 3%), marked effect in 45 cases( 75%),progress in 10 cases( 16. 7%),and ineffective in 0 case( 0%),with a controlled and effective rate of 83. 3%,control group: clinical control in 7 cases( 11. 7%),marked effect in 41 cases( 68. 3%),progress in 12 cases( 20%),and ineffective in 0 case( 0%),with a controlled and effective rate of 80%. TCM syndrome grading and classification scale results were as follows,experimental group: clinical control in 4 cases( 6. 7%),marked effect in 47 cases( 78. 3%),progress in 9 cases( 15%),and ineffective in 0 case( 0%),with a controlled and effective rate of 85. 0%,control group: clinical control in 6 cases( 10%),marked effect in 46 cases( 76. 7%),progress in 8 cases( 13. 3%),and ineffective in 0 case( 0%),with a controlled and effective rate of 86. 7%.Statistically,there was significant difference before and after treatment in both groups( P〈0. 01), but the difference wa
作者 周荣易 韩新民 雷爽 孙继超 尤月 范秋婷 ZHOU Rong-yi, HAN Xin-min , LEI Shuang, SUN Ji-chao, YOU Yue, FAN Qiu-ting (Nanjing University of Chinese Medicine, Nangjing 210023, China)
机构地区 南京中医药大学
出处 《中国实验方剂学杂志》 CAS CSCD 北大核心 2016年第10期148-153,共6页 China Journal of Experimental Traditional Medical Formulae
基金 国家自然科学基金面上项目(81273801)
关键词 多发性抽动症 安神定志灵 耶鲁综合抽动严重程度量表 Tourette syndrome Anshen Dingzhiling Yale Global Tic Severity Scale
作者简介 [第一作者]周荣易,在读博士,从事小儿精神神经系统疾病研究,E-mail:zhourongyitcm@sina.com [通讯作者]韩新民,教授,主任医师,博士生导师,从事小儿精神神经系统疾病研究,E-mail:hxmlnj@163.com
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