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Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus

Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus
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摘要 Zika 的最近的爆发在大洋洲岛和美洲的病毒(ZIKV ) 感染被盒子的高数字和病毒的传播描绘到新区域。更好理解 ZIKV 的起源,它的流行历史被考察。尽管可得到的记录和信息是有限的, ZIKV 的二个主要的基因系在以前的研究被识别。在这研究,然而,三个系从 GenBank 基于所有病毒序列的种系发生的分析被识别,信封蛋白质(E) 和非结构的蛋白质包括那些 5 (NS5 ) 编码区域。位于他们的分叉和进化下面的三个识别 ZIKV 系和再结合事件和机制的空间、时间的分布进一步被详细描述。ZIKV 的潜在的迁居小径也被描绘。我们的调查结果揭示了二个非洲的国家,塞内加尔和笼 dIvoire 的中央角色,在 ZIKV 进化和 genotypic 分叉。而且,我们的结果建议在亚洲和和平的岛的爆发从非洲发源。结果提供卓见进 ZIKV 爆发的地理起源和病毒的传播,并且也贡献 ZIKV 进化的更好的理解,它为 ZIKV 感染的预防和控制是重要的。 Recent outbreaks of Zika virus (ZIKV) infections in Oceania's islands and the Americas were characterized by high numbers of cases and the spread of the virus to new areas. To better understand the origin of ZIKV, its epidemic history was reviewed. Although the available records and information are limited, two major genetic lineages of ZIKV were identified in previous studies. However, in this study, three lineages were identified based on a phylogenetic analysis of all virus sequences from GenBank, including those of the envelope protein (E) and non-structural protein 5 (NS5) coding regions. The spatial and temporal distributions of the three identified ZIKV lineages and the recombination events and mechanisms underlying their divergence and evolution were further elaborated. The potential migration pathway of ZIKV was also characterized. Our findings revealed the central roles of two African countries, Senegal and Cote d'lvoire, in ZIKV evolution and genotypic divergence. Furthermore, our results suggested that the outbreaks in Asia and the Pacific islands originated from Africa. The results provide insights into the geographic origins of ZlKV outbreaks and the spread of the virus, and also contribute to a better understanding of ZlKV evolution, which is important for the prevention and control of ZlKV infections.
作者 Shu Shen Junming Shi Jun Wang Shuang Tang Hualin Wang Zhihong Hu Fei Deng Shu Shen(1) ; Junming Shi(1) ; Jun Wang(1) ; Shuang Tang(1) ; Hualin Wang(1) ; Zhihong Hu(1) ; Fei Deng(1) ;
出处 《中国病毒学:英文版》 CAS CSCD 2016年第2期118-130,共13页 Virologica Sinica
基金 supported by the Science and Technology Basic Work Program(2013FY113500)from the Ministry of Science and Technology of China
关键词 病毒基因序列 系统发育分析 非洲国家 演变 传播 地理起源 非结构蛋白 基因型差异 Flaviviridae Zika virus (ZIKV) phylogenetic analysis lineages recombination migration
作者简介 Correspondence: Phone: +86-27-87198465, Fax:+86-27-87198465 Email:df@wh.iov.cn ORCID:0000-0002-5385-083X
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