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贲门失弛缓症动物模型制备的研究进展 被引量:1

Research Progress of Animal Model of Esophageal Achalasia
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摘要 目的了解贲门失弛缓症动物模型制备的研究进展以及简要探讨贲门失弛缓症的发病机制。方法查阅近年来有关贲门失弛缓症动物模型制备的相关文献并进行分析总结。结果多种动物模型如梗阻模型、经典的去神经模型和近年来研究热门的基因模型,它们都可以实现贲门失弛缓症的造模,且它们都是基于相应的病因学说,施以不同的处理因素,从而完成模型的制备。结论贲门失弛缓症动物模型制备,主要经历了梗阻—去神经—基因三个阶段。基于先天性学说从基因层次出发的基因模型可以更好地认识和了解这个疾病,可制造出理想的动物模型,可以为贲门失弛缓症的病因学研究提供可靠的依据。 Objective To understand research progress of animal model of esophageal achalasia and discuss its pathogenesis briefly. Method Literatures about research progress of animal model of esophageal achalasia were reviewed. Results The models of esophageal achalasia could been made in several ways, such as the obstruction model, the classic denervation model, and the increasingly popular gene model. These models were all based on the theory of the corresponding causes, with the processing of different factors, then completed the preparation of animal model. Conclusions Animal model of esophageal achalasia goes through three stages: obstruction model, denervation model, and gene model. Gene model of esophageal achalasia based on congenital theory could help us understand this disease better and make an ideal animal model, which could provide a reliable evidence for etiology study.
作者 张龙龙 王根旺 钱彬彬 顾越雷 杨孙虎 ZHANG Long-long, WANG Gen-wang, QIAN Bin-bin, GU Yue-lei, YANG Sun-hu. (Department of General Surgery, Shanghai Third People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201900, China)
出处 《中国普外基础与临床杂志》 CAS 2016年第5期638-640,F0003共4页 Chinese Journal of Bases and Clinics In General Surgery
关键词 贲门失弛缓症 动物模型 梗阻模型 去神经模型 基因模型 Esophageal achalasia Animal model Obstruction model Denervation model Gene model
作者简介 张龙龙(1992年-),男,浙江省金华市人,硕士在读,主要研究方向为胃肠道疾病,E-mail:1710485649@qq.com 通信作者:杨孙虎,E-mail:yangsh06@126.com
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参考文献35

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