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清胆和胃汤治疗胆热犯胃型胆汁反流性胃炎的临床研究

Clinical study of Qingdan Hewei Decoction on bile reflux gastritis with gallbladder heat invading stomach
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摘要 目的:探讨清胆和胃汤治疗胆热犯胃型胆汁反流性胃炎可能作用机制。方法:将符合纳入标准的132例病例按随机数字生成法分为治疗组和对照组,治疗组给予清胆和胃汤免煎颗粒,对照组给予复方铝酸铋颗粒,用ELISA法观察干预前后治疗组和对照组患者血浆胃饥饿素(Ghrelin)、环氧化酶1(COX-1)、环氧化酶2(COX-2)和前列腺素E2(PGE2)表达水平。方法:观察ELISA法干预前后治疗组和对照组患者血浆Ghrelin、COX-1、COX-2和PGE2表达水平。结果:治疗后两组血浆Ghrelin、COX-1、PGE2水平均明显升高(P<0.01),其中治疗组明显高于对照组(P<0.01)。治疗后两组COX-2明显降低(P<0.01),而治疗组明显低于对照组(P<0.01)。结论:清胆和胃汤治疗胆热犯胃型胆汁反流性胃炎的作用机制可能是通过调节Ghrelin/COX-PG系统来实现的,一方面是通过Ghrelin促胃肠动力的作用使胆汁反流的状况得到明显缓解,另一方面通过Ghrelin对PGE2的调节来实现对胃黏膜的损伤修复。 Objective: Discussing the possible mechanism of Qingdan Hewei Decoction in the treatment of bile reflux gastritis with gallbladder heat invading stomach. Methods: One hundred and thirty-two cases who met the inclusion criteria were divided into treatment group and control group by random number generation method. The treatment group was given free decoction granules of Qingdan Hewei Decoction, and the control group was given Compound Bismuth Aluminate Granules.The expression levels of plasma Ghrelin, COX-1, COX-2 and PGE2 were observed in the treatment group and control group before and after intervention by ELISA method. Results: After treatment, the levels of the Ghrelin, COX-1 and PGE2 in plasma of the two groups were significantly increased(P<0.01), and the level of the treatment group was significantly higher than that of control group(P<0.01). The level of plasma COX-2 in the two groups were significantly decreased(P<0.01), and the level of the treatment group was significantly lower than that in the control group(P<0.01). Conclusion: The mechanism of Qingdan Hewei Decoction in the treatment of bile reflux gastritis with gallbladder heat invading stomach may be through regulating ghrelin/COXPG system. On the one hand, Ghrelin promotes gastrointestinal motility to relieve bile reflux, on the other hand, Ghrelin regulates PGE2 to repair gastric mucosal lesions.
作者 黄大未 王建云 安丽 魏玥 严利依 黄昱璋 杨晋翔 HUANG Da-wei;WANG Jian-yun;AN Li;WEI Yue;YAN Li-yi;HUANG Yu-zhang;YANG Jin-xiang(Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou 310006,China;Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China;Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020,China;Beijing University of Chinese Medicine,Beijing 100029,China)
出处 《中华中医药杂志》 CAS CSCD 北大核心 2019年第3期1287-1289,共3页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 “首都临床特色应用研究”专项项目(No.Z131107002213086).
关键词 胆汁反流性胃炎 胆热犯胃 清胆和胃汤 杨晋翔 胃饥饿素 环氧化酶1 环氧化酶2 前列腺素E2 Bile reflux gastritis Gallbladder heat invading stomach Qingdan Hewei Decoction YANG Jin-xiang Ghrelin COX-1 COX-2 PGE2
作者简介 通讯作者:杨晋翔,北京市朝阳区安外小关51号北京中医药大学第三附属医院,邮编:100029,电话:010-52075325,E-mail:yjx571102@163.com.
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