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性别差异对于原发性高血压患者脑卒中风险的影响 预览 被引量:2

Gender differences in stroke risk among patients with hypertension
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摘要 目的高血压是脑卒中危险因素中重要的可干预因素,寻找出性别差异对于卒中风险的影响,从而为制订针对性的防治策略提供依据。方法收集2 258例原发性高血压患者的病例资料,包括年龄、性别、烟酒嗜好、收缩压(SBP)/舒张压(DBP)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、空腹血糖(GLU)、同型半胱氨酸(Hcy)以及疾病既往史等,采用Logistic回归模型分析脑卒中危险因素以及Lg Hcy和各危险因素之间的交互作用。结果 2 258例原发性高血压患者中,女性患者SBP、GLU、TC、HDL-C、非HDL-C、TG的水平以及合并糖尿病和高脂血症的比例均较男性患者显著升高(P〈0.05),但是女性患者Hcy血浆含量和吸烟、饮酒、高同型半胱氨酸血症比例较男性患者明显降低(P〈0.05)。男女患者罹患脑卒中的独立危险因素包括糖尿病、吸烟、SBP/DBP、Lg Hcy的升高以及HDL-C的降低,但是在女性患者除了上述危险因素外,还包括TG的升高(P〈0.05)。女性患者Lg Hcy和SBP、DBP、TG之间的交互作用增加脑卒中的患病风险(P〈0.05),但是男性患者仅Lg Hcy和DBP的交互作用增加脑卒中的患病风险(P〈0.05)。结论针对原发性高血压患者,无论男女,降低SBP/DBP水平,均可明显减少脑卒中的发生。血浆Hcy含量的升高是脑卒中的独立危险因素。在不同性别,Hcy又通过与不同危险因素的交互作用而增加卒中患病风险,这些差异应该在高血压的治疗中予以重视。 Objective Hypertension is the most common modifiable risk factor for stroke in both men and women. Now more than ever,it is critical to identify gender differences at higher risk for stroke and initiate the appropriate prevention strategies. Methods Detailed information of 2 258 patients with essential hypertension were collected including age, gender, body height, body weight, smoking, alcohol drinking, systolic pressure( SBP)/diastolic pressure(DBP) ,total cholesterol(TC) ,high-density lipoprotein cholesterol ( HDL-C ), triglycerides ( TG ), fasting glucose ( GLU ), homocysteine (Hcy ), and past history of diabetes mellitus, hyperlipemia, stroke and hyperhomocysteinemia. We examined the relative risks for stroke in hypertension patients and the detectable interaction effects of Hey and stratified factors on predicting the risk of stroke by using logistic regression models between men and women, respectively. Results In 2 258 hypertension patients ,women had higher levels of SBP, fasting GLU, TC, HDL-C, non-HDL-C and TG, and had higher prevalences of diabetes mellitus and hyperlipidemia than men ( P 〈 0. 05 ). The concentration of Hcy was statistically lower in women than men, as was also their exposure to environmental cigarette smoking, alcohol consumption and hyperhomocysteinemia ( P 〈 0. 05 ). Independent predictors of stroke contained diabetes mellitus, cigarette smoking, high SBP/DBP elevated Log Hcy, and decrease in HDL-C level in both men and women ( P 〈 0. 05 ). In addition, TG was another risk factor to prevalent stroke for women ( P 〈 0. 05 ). Significant interactions on stroke risk were observed between Log Hcy and other risk factors including SBP, DBP and TG in women (P 〈 0. 05 ). But in men, we found the interaction between Log Hcy and DBP in relation to the risk of stroke (P 〈 0.05 ). Conclusions The effects of intervention to lower blood pressure and thereby reduce the risk of stroke on hypertension patients are proved. Women benefit
作者 庞慧 韩冰 李先池 付强 Pang Hui, Han Bing, Li Xianchi , Fu Qiang( 1 Department of Cardiovascular Medicine, Central Hospital of Xuzhou,Xuzhou 221009, China ;2 Xuzhou Clinical School ,Xuzhou Medical College ,Xuzhou 221009, China)
出处 《中华脑科疾病与康复杂志(电子版)》 2016年第1期14-19,共6页
关键词 高血压 脑卒中 性别因素 同型半胱氨酸 Hypertension Stroke Gender factors Homocysteine
作者简介 通讯作者:庞慧,Email:phui81@126.com
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  • 1Pennell LM, Galligan CL, Fish EN. Sex affects immunity [ J ]. J Autoimmun,2012,38 (2/3) :J282-J291. 被引量:1
  • 2Rauch U. Gender differences in anticoagulation and antithrombotic therapy [ J ]. Handb Exp Pharmacol,2012 ( 214 ) : 523-542. 被引量:1
  • 3Haast RA, Gustafson DR, Kiliaan AJ. Sex differences in stroke [ J ]. J Cereb Blood Flow Metab,2012,32(12) :2100-2107. 被引量:1
  • 4Yang G, Wang Y, Zeng Y, et al. Rapid health transition in China, 1990-2010 :findings from the Global Burden of Disease Study 2010 [ J]. Lancet,2013,381 (9882) : 1987-2015. 被引量:1
  • 5Liu M, Wu B, Wang WZ, et al. Stroke in China: epidemiology, prevention, and management strategies [ J ]. Lancet Neurol, 2007, 6(5 ) :456-464. 被引量:1
  • 6Wieberdink RG, Ikram MA, Hofman A, et al. Trends in stroke incidenee rates and stroke risk factors in Rotterdam, the Netherlands from 1990 to 2008 [ J ]. Eur J Epidemio1,2012,27 (4) : 287-295. 被引量:1
  • 7Appelros P, Stegmayr B, Terent A. Sex differences in stroke epidemiology: a systematic review [ J ]. Stroke, 2009, 40 ( 4 ) : 1082-1090. 被引量:1
  • 8Saeeo S, Totaro R, Toni D, et al. Incidence, case-fatalities and lO- year survival of subarachnoid hemorrhage in a population-based registry[ J]. Eur Neuro1,2009,62 ( 3 ) : 155-160. 被引量:1
  • 9Eden SV, Meurer WJ, S6nchez BN, et al. Gender and ethnic differences in subarachnoid hemorrhage [ J ]. Neurology, 2008, 71 (10) :731-735. 被引量:1
  • 10Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics-2013 update:a report from the American Heart Association [ J]. Circulation ,2013,127 ( 1 ) : e6-e245. 被引量:1

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