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加味生脉补心丹对冠心病气虚血瘀证大鼠动脉粥样硬化的影响 预览 被引量:2

Effect of Jiawei Shengmai Buxin Decoction on Coronary Atherosclerosis in Rats with Qi Deficiency and Blood Stasis
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摘要 目的 制备模拟人类发病过程的大鼠冠心病模型,初步探讨加味生脉补心丹对动脉粥样硬化的影响及干预机制。方法 将30只大鼠分为正常组、模型组、西药组、中药高、低剂量组,正常组予普通饲料喂养,其余组高糖高脂饲料喂养5周,第6周造模组采用腹腔3次注射垂体后叶素制备冠心病心肌缺血模型。中药高、低剂量组予加味补心丹药液2.25、0.75 g/m L剂量灌胃,西药组予单硝酸异山梨酯药液灌胃,连续18周。观察各组对空腹血糖、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脂联素、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、心肌病理切片和主动脉弓切片结果的影响。结果 1)与正常组比较,模型组的TG、TC、LDL-C、脂联素水平降低,HDL-C、IL-6、TNF-α、CRP、FBG升高。2)与模型组比较,中药组和西药组的动脉粥样硬化程度降低,斑块程度下降;中药组和西药组的心肌纤维化程度降低,心肌受损程度下降。中药组和西药组的外在表现均优于模型组;中药组和西药组TG、TC、LDL-C的值降低,HDL-C的值升高;脂联素水平升高,IL-6、TNF-α、CRP降低。结论 加味生脉补心丹组可以降低冠心病大鼠的血糖、血脂,抗动脉粥样硬化及抗心肌纤维化,机制可能与改善脂联素水平和改善炎症反应有关。 Objective: To prepare coronary heart disease (CHD) in rats model similar to human disease process, and observe the effect of Jiawei shengmai buxin Decoction on atherosclerosis,and discuss its intervention mechanism. Methods: After ordinary adaptive feed for 1 w, 30 rats were divided into the normal group (n = 6), the mod- el group (n = 6) ,western medicine group (n = 6) ,high-dose group (n = 6) ,low-dose group (n = 6). The ordinary groups were normally fed,while the rest were fed with high sugar and high fat feed for 5 w. In 6th week,modules were made with 10% chloral hydrate with intraperitoneal injection of 0.3 g/kg,supine position fixed in rats after anesthesia on stage, connecting physiological recorder, recording a standard Ⅱ lead electrocardiogram of rats. later,the model group received injection of pituitrin 6 U/kg (1 concentration for 2 U/m) with 5 s constant speed;the normal group received normal amount of saline injection,3 times,each time interval of 15 days. According to the following methods,the indicators were observed. After validation of coronary heart disease,myocardial ischemia model was established ;they continued being fed with high sugar and high fat feed for 18 weeks. The effects of Jiawei Jiawei shengmai buxin Decoction on fasting blood glucose,serum total cholesterol,triglyceride,low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol ( HDL-C ), adiponectin, TNF, IL-6, CRP were observed ,as well as the results of myocardial pathologic biopsy and the aortic arch. Results: 1 )Compared with the normal group,in the model group,TG,TC,LDLC ,and adiponectin level reduced,and HDLC ,IL-6,TNF-α, CRP and FBG rose. 2)Compared with the model group,in traditional Chinese medicine and western medicine groups the extent of atherosclerosis reduce, as well as plaque, myocardial fibrosis degree, myocardial damage. The outward sign of traditional Chinese medicine group and western medicine groups were better than those of the model gro
作者 潘继兴 邓文祥 曾光 陈青扬 吴华英 李亮 刘平安 何军峰 黄惠勇 PAN Jixing,DENG Wenxiang,ZENG Guang,et al(Changsha Hospital of Traditional Chinese Me dieine(Changs ha Eighth Hospital), Hunan , Changsha 410208, Chino.)
出处 《中国中医急症》 2016年第7期1303-1306,共4页 Journal of Emergency in Traditional Chinese Medicine
基金 国家自然科学基金面上项目(81373551) 教育部博士点博士导师课题(20134323110001) 湖南省科技厅社会发展支撑计划重点项目(2014S2032) 湖南省中医药科研计划项目(2014153) 湖南省研究生创新课题(CX20158332) 湖南中医药大学中医诊断学国家重点学科开放项目(2013ZYZD04,2014-5,2014-28,2015ZYZD32) 湖南省学位与研究教育教学改革研究课题(JG20158068)
关键词 加味生脉补心丹 中药 冠心病 心肌缺血 动脉粥样硬化 Jiawei shengmai buxin Decoction Traditional Chinese medicine (TCM) Coronary heart disease Myocardial ischemia Atherosclerosis
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