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老年冠心病患者PCI术后气虚血瘀证对抗栓疗效的影响及其与CYP2C19*2基因多态性的相关性 预览 被引量:7

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摘要 目的 探讨老年冠心病患者经皮冠状动脉介入治疗(PCI)术后气虚血瘀证对抗栓疗效的影响及其与CYP2C19*2基因多态性的相关性。方法 选择行PCI术后老年冠心病患者302例作为研究对象,PCI术后1个月根据中医辨证分型分为气虚血瘀型(观察组,121例)和非气虚血瘀型(对照组,181例)。通过动态心电图(AECG)检测是否存在无症状心肌缺血(SMI);比较两组患者临床资料、抗栓疗效与CYP2C19*2基因型分布。结果 两组患者的年龄、性别、合并高血压的比例差异显著(P均〈0.05);两组的SMI与非SMI比例无显著差异(P〉0.05);观察组的最大血小板聚集率、血浆血管性假血友病因子高于对照组(P均〈0.05);观察组CYP2C19*2 GA+AA基因型(弱代谢型)所占比例明显高于对照组(P〈0.05);多因素Logistic回归分析提示,性别、CYP2C19弱代谢型是气虚血瘀证的危险因素,女性患者、CYP2C19*2基因突变型患者在PCI术后更易出现气虚血瘀证。结论 老年冠心病患者PCI术后气虚血瘀证患者存在血管内皮损伤及血小板活化,气虚血瘀证和CYP2C19*2基因型突变有关,这种表现在女性患者中更有意义。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第14期3417-3419,共3页 Chinese Journal of Gerontology
基金 浙江省中医药科学研究基金计划(No.2012ZA011)
作者简介 郭环宇(1981-),女,硕士,主治医师,主要从事老年病学研究。
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参考文献15

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