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Association of Polymorphisms of rs179247 and rs12101255 in Thyroid Stimulating Hormone Receptor Intron 1 with an Increased Risk of Graves' Disease:A Meta-analysis 预览

Association of Polymorphisms of rs179247 and rs12101255 in Thyroid Stimulating Hormone Receptor Intron 1 with an Increased Risk of Graves' Disease:A Meta-analysis
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摘要 The polymorphisms of thyroid stimulating hormone receptor(TSHR) intron 1 rs179247 and rs12101255 have been found to be associated with Graves’ disease(GD) in genetic studies. In the present study, we conducted a meta-analysis to examine this association. Two reviewers systematically searched eligible studies in Pub Med, Web of Science, Embase and China Biomedical Literature Database(CBM). A meta-analysis on the association between GD and TSHR intron 1 rs179247 or rs12101255 was performed. The odd ratios(OR) were estimated with 95% confidence interval(CI). Meta package in R was used for the analyses. Seven articles(13 studies) published between 2009 and 2014, involving 5754 GD patients and 5768 controls, were analyzed. The polymorphism of rs179247 was found to be associated with an increased GD risk in the allele analysis(A vs. G: OR=1.40, 95% CI=1.33–1.48) and all genetic models(AA vs. GG: OR=1.94, 95% CI=1.73–2.19; AA+AG vs. GG: OR=1.57, 95% CI=1.41–1.74; AA vs. AG+GG: OR=1.54, 95% CI=1.43–1.66). The site rs12101255 also conferred a risk of GD in the allele analysis(T vs. C: OR=1.50, 95% CI=1.40–1.60) and all genetic models(TT vs. CC: OR=2.22, 95% CI=1.92–2.57; TT+TC vs. CC: OR=1.66, 95% CI=1.50–1.83; TT vs. TC+CC: OR=1.74, 95% CI=1.53–1.98). Analysis of the relationship between rs179247 and Graves’ ophthalmopathy(GO) showed no statistically significant correlation(A vs. G: OR=1.02, 95% CI=0.97–1.07). Publication bias was not significant. In conclusion, GD is associated with polymorphisms of TSHR intron 1 rs179247 and rs12101255. There is no association between rs179247 SNPs and GO. The polymorphisms of thyroid stimulating hormone receptor(TSHR) intron 1 rs179247 and rs12101255 have been found to be associated with Graves' disease(GD) in genetic studies. In the present study, we conducted a meta-analysis to examine this association. Two reviewers systematically searched eligible studies in Pub Med, Web of Science, Embase and China Biomedical Literature Database(CBM). A meta-analysis on the association between GD and TSHR intron 1 rs179247 or rs12101255 was performed. The odd ratios(OR) were estimated with 95% confidence interval(CI). Meta package in R was used for the analyses. Seven articles(13 studies) published between 2009 and 2014, involving 5754 GD patients and 5768 controls, were analyzed. The polymorphism of rs179247 was found to be associated with an increased GD risk in the allele analysis(A vs. G: OR=1.40, 95% CI=1.33–1.48) and all genetic models(AA vs. GG: OR=1.94, 95% CI=1.73–2.19; AA+AG vs. GG: OR=1.57, 95% CI=1.41–1.74; AA vs. AG+GG: OR=1.54, 95% CI=1.43–1.66). The site rs12101255 also conferred a risk of GD in the allele analysis(T vs. C: OR=1.50, 95% CI=1.40–1.60) and all genetic models(TT vs. CC: OR=2.22, 95% CI=1.92–2.57; TT+TC vs. CC: OR=1.66, 95% CI=1.50–1.83; TT vs. TC+CC: OR=1.74, 95% CI=1.53–1.98). Analysis of the relationship between rs179247 and Graves' ophthalmopathy(GO) showed no statistically significant correlation(A vs. G: OR=1.02, 95% CI=0.97–1.07). Publication bias was not significant. In conclusion, GD is associated with polymorphisms of TSHR intron 1 rs179247 and rs12101255. There is no association between rs179247 SNPs and GO.
作者 巩静 姜淑君 王定坤 董慧 陈广 方珂 崔金锐 陆付耳 Jing GONG, Shu-jun JIANG, Ding-kun WANG, Hui DONG ,Guang CHEN, Ke FANG, Jin-rui CUI, Fu-er LU(1.Instimte of Integrated Traditional Chinese and Western Medicine, 2Department of Nursing Care, College, Huazhong University of Science and Technology, Wuhan 430030, China)
出处 《华中科技大学学报:医学英德文版》 SCIE CAS 2016年第4期473-479,共7页 Journal of Zuazhong University of Science and Technology: Medical Edition
基金 supported by the National Natural Science Foundation of China(Nos.81273683,81473637)
关键词 受体基因 内含子 多态性 促甲状腺激素 风险 甲状腺激素受体 医学文献数据库 Meta分析 Graves' disease Graves' ophthalmopathy genetic polymorphism meta-analysis
作者简介 Jing GONG, E-mail: jgongtcm@126.com Corresponding author, E-mail: felu@tjh.tjmu.edu.cn
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