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舒肝解郁胶囊对抑郁模型大鼠脑内5-HT、DA及其代谢产物水平的影响 预览 被引量:11

Effect of Shugan Jieyu Capsules on 5-HT, DA and their Metabolites in the Brain of Depression Model Rats
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摘要 目的研究舒肝解郁胶囊对抑郁模型大鼠脑内5-HT、DA及其代谢产物水平的影响。方法将28只雄性SD大鼠随机分成正常对照组、模型组、舒肝解郁组、氟西汀组四组;采用慢性轻度不可预见性应激(CUMS)结合孤养方式建立抑郁大鼠模型,舒肝解郁组和氟西汀组大鼠于造模同时分别给予舒肝解郁胶囊和氟西汀干预;用库仑阵列电化学高效液相色谱法分别检测大鼠内侧前额叶皮质(mPFC)及海马CA3区5-HT、DA及其代谢产物的含量。结果应激21 d后,模型组与正常对照组比较,大鼠mPFC区5-HT、5-羟吲哚乙酸(5-HIAA)、DA和高香草酸(HVA)的浓度均显著降低,差异有统计学意义(P〈0.01),海马CA3区5-HT、DA和5-HIAA的浓度均显著降低,差异有统计学意义(P〈0.05);与模型组比较,舒肝解郁组和氟西汀组可显著增加大鼠mPFC区5-HT、DA和HVA浓度,差异有统计学意义(P〈0.01或P〈0.05),海马CA3区5-HT、DA和5-HIAA浓度显著升高,差异有统计学意义(P〈0.05)。结论舒肝解郁胶囊能增强抑郁模型大鼠中枢5-HT和DA神经递质系统的功能,这可能是其抗抑郁作用的神经生化机制之一。 Objective To evaluate the effect of Shugan Jieyu (SGJY) capsules on 5-HT, DA and their metabolites in the brain of depression model rats. Methods Twenty-eight male SD rats were randomly divided into normal control group, model group, SGJY group and fluoxetine group. We established the depression rat models with the method of chronic unpredictable mild stress (CUMS) and separate feeding. The SGJY group anf fluoxetine group were intervened with SGJY capsule and fluoxetine. The 5-HT, DA and their metabolites levels in medial prefrontal cortex (mPFC) and hippoeampal CA3 areas were detected by HPLC- ECD method. Results After 21 days" stress, compared with the control group, the levels of 5-HT, 5-hydroxyindoleaeetic acid (5- HIAA), DA and homovanillie acid (HVA) in the mPFC of depression model rats were significantly decreased (P〈0.01), and the levels of 5-HT, 5-HIAA and DA in hippocampal CA3 area were significantly decreased (P〈0.05). Compared with model group, the levels of 5-HT, DA and HVA in the mPFC of fluoxetine and SGJY groups were significantly increased (P〈0.01 or P〈0.05), and the levels of 5-HT, DA and 5-HIAA in hippoeampal CA3 area were significantly increased (P〈0.05). Conclusion The SGJY capsule could increase the function level of DA and 5-HT neurotransmitter systems in mPFC and hippoeampus areas of depression model rats.
作者 傅锦华 刘勇 FU Jinhua, LIU Yong ( 1.Department of Psychiatry, Brain Hospital of Hunan Province, Changsha, Hunan 410007, China; 2.Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China)
出处 《湖南中医药大学学报》 CAS 2016年第6期47-51,共5页 Journal of Traditional Chinese Medicine University of Hunan
关键词 舒肝解郁胶囊 抑郁症 慢性轻度不可预见性应激 5-羟色胺 多巴胺 贯叶金丝桃 刺五加 SGJY capsules depression chronic unpredictable mild stress 5-HT DA Hypericum pesforcaum aeanthopanax senticosus
作者简介 傅锦华,女,博士,副主任医师,研究方向:精神病的药理研究。
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