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地塞米松联合血小板生成素及环孢素治疗免疫性血小板减少症的疗效观察 预览 被引量:3

Efficacy of dexamethasone in combination with thrombopoietin and ciclosporin in the treatment of immune thrombocytopenia
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摘要 目的探讨大剂量地塞米松(dexamethasone,DXM)联合重组人血小板生成素(recombinant human thrombopoietin,rh TPO)及环孢素(ciclosporin,Cs)治疗免疫性血小板减少症(immune thrombocytopenia,ITP)的疗效。方法将55例ITP患者随机分为2组,观察组使用DXM、rh TPO及Cs,对照组使用DXM、rh TPO,对比2组近期疗效、远期疗效及不良反应。结果 2组近期疗效差异无统计学意义,远期疗效观察组明显优于对照组(P〈0.05);2组各有1例因DXM不良反应减量使用。结论对使用DXM和rh TPO近期疗效良好的ITP患者,加用Cs治疗后可提高远期疗效。 Objective To investigate the treatment efficacy of immune thrombocytopenia( ITP) by high-dose dexamethasone combined with thrombopoietin and ciclosporin( Cs). Methods Fifty-five cases of immune thrombocytopenia patients were randomly divided into two groups,the observation group with dexamethasone,recombinant human thrombopoietin( rh TPO) and Cs,and the control group with dexamethasone and rh TPO. The short-term effect,long-term efficacy and side effects between the two groups were compared. Results There were no significant differences in short-term effect,long-term efficacy in observation group was significantly better than that in the control group. One case in each group reduce the dosage of dexamethasone for side effects. Conclusion Addition of Cs in patients with ITP who have recent good effects after the use dexamethasone and rh TPO can improve the long-term effectiveness.
作者 郭宏岗 王佳佳 岑坚 刘毅 沈建良 GUO Honggang1,2,WANG Jiajia3,CEN Jian1,LIU Yi2,SHEN Jianlian2(1. Postgraduate School, Anhui Medical University, Helei Anhui 230032, China;2. Department of Hematology, Navy General Hospital,Beijing 100048, China;3. Department of Hematology,the 155th Central Hospital of PLA,Kaileng He'nan 475003, China)
出处 《转化医学杂志》 2016年第5期279-282,297共5页 Translational Medicine Journal
关键词 免疫性血小板减少症 血小板生成素 环孢素 联合治疗 Immune thrombocytopenia(ITP) Thrombopoietin Ciclosporin(Cs) Combination therapy
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