Objective To explore the relationship between peripheral blood coagulation in- dexes and clinical pathological characteristics and chemotherapy in patients with gastric cancer. Methods A total of 120 patients with gastric cancer were selected as observation group, and 100 healthy people were selected as control group. The TT, AFFF, PT, FIB, PLT, D-D were compared between the two groups, and peripheral blood coagulation indexes were compared among gastric canc- er patients with different clinical pathological characteristics. Results There were no significant differences in AFIT, FF between the two groups （P 〉 0.05 ）. TT in the observation group was signif- icantly lower and FIB, D-D, PLT were significantly higher than the control group （P 〈 0.05 ）. In the observation group, TT and PLT in the male patients were significantly lower than the female （P 〈 0.05 ）, FIB and D-D in the younger patients were significantly lower than the elderly patients （ P 〈 0.05 ） , FIB and PLT in tumor invasion shallower patients were significantly lower than invasion deeper （P 〈0.01 ） , PT, FIB, D-D, PLT in the lower stage were significantly lower than the higher stage （P 〈 0.01 ）. TT in lower differentiation was significantly lower, and PLT was higher than those with higher differentiation （P 〈 0.05 ）, D-D and PLT in patients without metastasis were significantly low- er than patients with metastasis （P 〈 0.05 ）. FIB and PLT after the chemotherapy were significantly lower than those before treatment （P 〈 0.05 ）. Conclusion The blood of patients with gastric cancer is in a state of high coagulation , and the symptoms are more serious in patients with conditions of female, old age, tumor invasion, higher stage, lower differentiation and metastasis.
Journal of Clinical Medicine in Practice
blood coagulation indexes