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外周血凝血指标与胃癌临床病理特征及化疗的相关性研究 预览 被引量:2

Relationship between peripheral blood coagulation indexes and clinical pathological characteristics and chemotherapy in patients with gastric cancer
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摘要 目的探讨外周血凝血指标与胃癌临床病理特征及化疗的相关性。方法120例胃癌患者作为观察组,100例健康人作为对照组,对比2组患者凝血酶时间(TT)、活化部分凝血活酶时间(AfyTT)、凝血酶原时间(胛)、血浆纤维蛋白原(FIB)、血小板计数(PLT)、D-二聚体(D-D)等外周血凝血指标,并对比不同临床病理特征胃癌患者的外周血凝血指标。结果2组APTT、PT比较无显著差异(P〉0.05),观察组1Tr显著低于对照组(P〈0.05),FIB、D-D、PLT均显著高于对照组(P〈0.01);胃癌患者中,男性,TT及PLT均显著低于女性(P〈0.05),年轻患者FIB、D-D显著低于年老患者(P〈0.05),肿瘤侵犯较浅者FIB及PLT显著低于侵犯较深者(P〈0.01),分期较低者PT、FIB、D-D、PLT显著低于分期较高者(P〈0.01),分化较低者TT显著低于分化较高者(P〈0.05),PLT显著高于分化较高者(P〈0.05),无转移者D-D与PLT均显著低于有转移者(P〈0.05);化疗后胃癌患者FIB及PLT均显著降低(P〈0.01)。结论胃癌患者血液呈高凝状态,且女性、老年、肿瘤侵犯较深、分期较高、分化较低、存在转移的患者更为严重。 Objective To explore the relationship between peripheral blood coagulation in- dexes and clinical pathological characteristics and chemotherapy in patients with gastric cancer. Methods A total of 120 patients with gastric cancer were selected as observation group, and 100 healthy people were selected as control group. The TT, AFFF, PT, FIB, PLT, D-D were compared between the two groups, and peripheral blood coagulation indexes were compared among gastric canc- er patients with different clinical pathological characteristics. Results There were no significant differences in AFIT, FF between the two groups (P 〉 0.05 ). TT in the observation group was signif- icantly lower and FIB, D-D, PLT were significantly higher than the control group (P 〈 0.05 ). In the observation group, TT and PLT in the male patients were significantly lower than the female (P 〈 0.05 ), FIB and D-D in the younger patients were significantly lower than the elderly patients ( P 〈 0.05 ) , FIB and PLT in tumor invasion shallower patients were significantly lower than invasion deeper (P 〈0.01 ) , PT, FIB, D-D, PLT in the lower stage were significantly lower than the higher stage (P 〈 0.01 ). TT in lower differentiation was significantly lower, and PLT was higher than those with higher differentiation (P 〈 0.05 ), D-D and PLT in patients without metastasis were significantly low- er than patients with metastasis (P 〈 0.05 ). FIB and PLT after the chemotherapy were significantly lower than those before treatment (P 〈 0.05 ). Conclusion The blood of patients with gastric cancer is in a state of high coagulation , and the symptoms are more serious in patients with conditions of female, old age, tumor invasion, higher stage, lower differentiation and metastasis.
作者 贺爱军 任羽 HE Aijun1, REN Yu2 ( 1. Department of General Surgery; 2. of Yan'an University, Department of Hematology, Affiliated Hospital Yan'an, Shaanxi, 716000)
出处 《实用临床医药杂志》 CAS 2016年第23期61-64,共4页 Journal of Clinical Medicine in Practice
基金 陕西省延安市人民政府资助项目(2013-3-46-R3)
关键词 凝血指标 胃癌 化疗 病理特征 blood coagulation indexes gastric cancer chemotherapy pathologic fea-tures
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