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胃液α-抗胰蛋白酶检测在胃癌诊断中的意义

Clinical Significance of Concentration Detection of Gastric Juice al-antitrypsin in Diagnosis of Gastric Cancer
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摘要 【目的】探讨胃液中α1-抗胰蛋白酶的检测对胃癌诊断的临床意义。【方法】选取2011年2月至2013年4月于本院行胃镜检查的114例胃癌(胃癌组)、43例胃部良性疾病(胃部良性疾病组)和25例健康人(对照组)为研究对象,采用ELISA法测定三组人员胃液中的α1-抗胰蛋白酶浓度,并进行统计学分析比较。【结果】胃癌组胃液中仪,-抗胰蛋白酶浓度[(1368.7±498.4)μg/dL]分别显著高于良性胃部疾病组[(345±96.5)μg/dL]和健康组[(31.2±17.3)μg/dL],且差异有统计学意义(P〈0.05);胃液α1-抗胰蛋白酶检测胃癌的敏感度、特异度、准确率分别为90.4%、89.7%、90.1%;Ⅲ-Ⅳ期胃癌患者胃液α1-抗胰蛋白酶浓度明显高于Ⅰ-Ⅱ期患者,差异具有统计学意义(P〈0.05)。【结论】检测胃液中α1-抗胰蛋白酶的浓度有助于提高胃癌的诊断准确率,有重要的临床应用价值,值得进一步研究及探讨。 [ Objective] To explore the clinical significance of detection of gastric juice cq-antitrypsin in diagnosis of gastric cancer. [ Methods ] 114 patients with gastric cancer (gastric cancer group), 43 patients with benign gas- tric diseases (benign gastric diseases group) and 25 healthy people (control group) who underwent upper gastrointes- tinal endoscopic examination in our hospital from February 2011 to April 2013 were selected as research subjects. The levels of concentration of gastric juice oh -antitrypsin of these three groups were examined respectively by ELISA. The experimental and clinical data were analyzed statistically. [ Results] The concentration of gastric juice oq-antitrypsin (1368.7 ±498.4) μg/dL in gastric cancer group was significantly higher than that in the benign gastric disease group (345 ± 96.5) μg/dL and the healthy group (31.2±17.3) μg/dL, and the difference was statistically significant ( P 〈 0.05 ) ; Gastric cancer sensitivity, specificity, accuracy of gastric juice oq-antitrypsin exams were 90. 4% , 89.7% and 90.1% ; the oh antitrypsin concentration of IU-Ⅳ gastric cancer patients was significantly higher than that of I - II patients, the difference was statistically significant ( P 〈 0.05 ). [ Conclusion] The concentration detection of oh-antitrypsin in gastric juice can improve the accuracy in the diagnosis of gastric cancer and has great clinical value of further studying.
作者 史向军 黄新余 汪昱 郑起 冯昌宁 SHI Xiang-jun, HUANG Xin-yu, WANG Yu,et al ( Department of General Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China )
出处 《医学临床研究》 CAS 2017年第1期17-19,共3页 Journal of Clinical Research
关键词 胃肿瘤/诊断 胃液 α-抗胰蛋白酶/代谢 Stomach Neoplasms/DI Gastric Juice alpha 1-Antitrypsin/ME
作者简介 通讯作者,E—mail:Huangxinyu77490@163.com
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