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噻托溴铵联合福莫特罗布地奈得吸入对COPD患者血清炎症因子及肺功能的影响 预览 被引量:17

The combination of tiotropium bromide inhalation Ronald Formoterol budesonide Effect of serum inflammatory factors and pulmonary function in patients with COPD
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摘要 目的探讨噻托溴铵联合福莫特罗布地奈得吸入对不同病程COPD患者血液中TNF-ɑ、IL-6、IL-8 3种细胞因子及肺功能变化的影响。方法选取我院呼吸内科住院的急性发作期COPD患者60例,随机分为联合应用噻托溴胺+布地奈德福莫特罗(联合治疗组),布地奈德福莫特罗组和噻托溴胺组,每组20例,共治疗12月,分别于治疗前、出院前、治疗后3个月、6个月、12个月检测患者血清细胞因子及肺功能;同时选取20名健康志愿者作为健康对照组。使用SPSS20.0软件进行统计学分析。结果 ①相对于对照组,急性发作期和缓解期的COPD患者的细胞炎症因子明显升高,肺功能明显降低(P均〈0.05)。②急性发作期的患者各炎症因子水平明显高于缓解期,肺功能水平明显低于缓解期患者(P均〈0.05)。③联合治疗组细胞因子降低水平、肺功能改善程度在缓解期不同时间段均明显优于其他两组(P均〈0.05),其他两组患者的细胞因子水平及肺功能改善情况无明显差异。结论联合应用噻托溴胺与布地奈德福莫特罗可以明显降低患者血清细胞炎症因子,减轻气道慢性炎症,改善肺功能。 Objective To investigate the effect of tiotropium combined Ronald Phu Mott Rob Di inhalation effect on blood different course in patients with COPD TNF-ɑ,IL-6,IL-8three kinds of cytokines and pulmonary function changes.Methods The hospitalized in hospital 60 cases of acute exacerbation of COPD patients were randomly divided into combined tiotropium + Bbu Di Ned Fumo Tero(treatment group),budesonide/formoterol and tiotropium group,20 cases in each group,were treated in December,respectively before treatment,the hospital before and after treatment 3month,6months,12 months of detection of serum cytokines and pulmonary function;20healthy volunteers were selected as healthy control group.Using SPSS20.0software for statistical analysis.Results Compared with the control group,the acute exacerbation and remission stage of COPD patients had significantly elevated inflammatory cytokines,pulmonary function was significantly reduced(P〈0.05).The levels of inflammatory factors in patients with acute exacerbation were significantly higher than those in remission stage,and the level of lung function was significantly lower than that in remission stage(P〈0.05).The combined treatment group decreased cytokine levels,improve lung function in remission at different time were significantly better than the other two groups(all P〈0.05),the other two groups of patients with cytokines and improve lung function have no obvious difference.Conclusion The combination of the application of the combination of the use of and Bu Di Ned Fumo Tero can significantly reduce the serum inflammatory cytokines in patients with chronic airway inflammation and improve lung function.
作者 李崇文 陈俊琦 王锦鸿 陈立文 LI Chong-wen , CHEN Jun-qi ,WANG J in-hong , et al. (Department of rehabilitation medicine, Dongpu branch, The First Affiliated Hospital of Jinan University, Guangzhou 510000, China)
出处 《中国实验诊断学》 2017年第2期214-217,共4页 Chinese Journal of Laboratory Diagnosis
关键词 慢性阻塞性肺疾病 细胞因子 肺功能 噻托溴胺 布地奈德福莫特罗 chronic obstructive pulmonary disease cytokine lung function tiotropium Formoterol budesonide
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