期刊文献+

不同类型乳腺黏液样癌的MRI征象及与生物学预后因子的相关性 预览 被引量:3

MRI Features of Mucinous Breast Carcinoma and the Correlation with Biological Prognostic Factors
在线阅读 下载PDF
分享 导出
摘要 【目的】探讨不同类型乳腺黏液样癌的MRI表现及与生物学预后因子的相关性。【方法】回顾性分析经病理组织学证实的35例乳腺单纯型黏液癌(PMBC)及15例混合型黏液癌(MMBC)的MRI资料,分析其形态学特征、T1WI及T2WI信号特点、动态增强模式、DWI信号及ADC值,并与分子生物学指标(ER、PR、CerbB-2、Her-2、Ki-67等)相对照。【结果】PMBC以椭圆形(16/35,45.7%)、圆形(10/35,28.6%)多见,且边界清晰(26/35,74.3%),多有分叶(31/35,88.6%);MMBC以不规则形(9/15,60%)多见,且边界不清(13/15,86.7%),以毛刺状及不规则边缘多见。PMBC与MMBC的T2WI信号不同,前者T2WI为明显高信号(33/35,94.3%),后者主要呈高低混杂信号(11/15,73.3%)。PMBC与MMBC的早期强化率分别为(114.7±9.1)%和(165.6±14.3)%;前者时间-信号强度曲线(TIC曲线)Ⅰ型28例,Ⅱ型7例,后者Ⅱ、Ⅲ型均为7例,Ⅰ型1例。PMBC的ADC值(1.91±0.06)×10~(-3)mm~2/s,MMBC约(1.13±0.08)×10~(-3)mm~2/s。两组间形态、边界、T2WI信号、早期强化率、TIC曲线、ADC值均有统计学差异(P〈0.05)。PMBC、MMBC患者的ER、PR、Cerb B-2阳性率无明显统计学差异,而Ki-67、Her-2阳性率MMBC显著高于PMBC(P〈0.05)。【结论】MRI可从形态、信号、动态增强及ADC值等多个方面鉴别PMBC与MMBC,其中PMBC影像征象更具特征性,分析其与生物学预后因子的相关性,间接提示MMBC较PMBC的预后较差。 【Objective】To explore the MRI features of the mucinous breast carcinoma and the correlation with biological prognostic factors.【Methods】MRI features of 35 pure and 15 mixed mucinous carcinomas were retrospectively analyzed.MR images were reviewed for shape,margin,the signal intensity,enhancement patterns of tumors and DWI features.All the patients were detected by immunohistochemical staining with expression of ER,PR,Cerb B-2,Ki-67 and Her-2.Correlations between the pure and mixed mucinous breast carcinoma and prognostic factors were analyzed.【Results】16 oval masses(16/35,45.7%)and 10 circular masses(10/35,28.6%)were found in 35 pure mucinous breast carcinomas with clear boundary(26/35,74.3%)and lobulated shape(31/35,88.6%);9 irregular masses(9/15,60%)were found in mixed mucinous breast carcinomas with unclear boundary(13/15,86.7%).Very high signal intensity on T2-weighted images was found in 33 pure mucinous carcinomas(33/35,94.3%)and 11 mixed mucinous carcinomas showed mixed signal intensity(11/15,73.3%).Early enhancement rate was(114.7 ± 9.1)% for pure mucinous carcinomas and(165.6 ± 14.3)% for mixed mucinous carcinomas.28 pure mucinous tumors demonstrated persistent enhancing pattern on time-signal intensity curve,7 pure mucinous tumors demonstrated plateau pattern and 7 mixed mucinous carcinomas showed plateau pattern and washout pattern respectively.Mean ADC value was(1.91 ± 0.06)×10~(-3)mm~2/s for pure mucinous carcinomas and(1.13±0.08)×10~(-3)mm~2/s for mixed mucinous carcinomas.There was significant difference with morphology,boundary,T2 WI signal,early enhancement rate,time-signal intensity curve,ADC value between pure and mixed mucinous breast carcinoma(P〈0.05).There was significant difference between pure and mixed mucinous breast carcinoma with Her-2 and Ki-67 expression(P〈0.05).【Conclusion】MRI could identify PMBC and MMBC from the shape,the signal intensity,dynamic enhancement and ADC value,and PMBC had distinc
作者 郭媛 孔庆聪 朱叶青 刘春玲 何晖 张金娥 杨蕊梦 江新青 GUO Yuan1, KONG Qing-cong2, ZHU Ye-qing2, LIU Chun-ling3, HE Hui3, ZHANG Jin-e3, YANG Rui- meng1, JIANG Xin-qing1( 1. Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China; 2. Department of Radiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China; 3. Department of Radiology, Guangdong Academy of Medical Seienees//Guangdong General Hospital, Guangzhou 510080, China)
出处 《中山大学学报:医学科学版》 CAS CSCD 北大核心 2017年第2期285-290,295共7页 Journal of Sun Yat-Sen University:Medical Sciences
基金 国家自然科学基金青年科学基金项目(81201087) 广东省省级科技计划项目(2014A020212232)
关键词 乳腺癌 黏液样癌 MRI 动态增强 弥散加权成像 breast cancer mucinous carcinoma MRI dynamic imaging DWI
作者简介 郭媛,硕士研究生,副主任医师,研究方向:乳腺MRI影像诊断,E-mail:gy042876@163.com; 刘春玲,通信作者:E-mail:10098030@qq.com
  • 相关文献

参考文献6

二级参考文献89

共引文献81

同被引文献21

引证文献3

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈