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云南汉族人群CD40基因多态性与肺癌发生发展的相关性 预览 被引量:1

The Correlation of CD40 Gene Polymorphisms with the Initiation and Development of Lung Cancer in Yunnan Han Population
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摘要 目的:探讨CD40基因多态性与云南汉族人群肺癌发生发展的相关性。方法:选取云南地区汉族人群肺癌Ⅰ+Ⅱ期患者151例、Ⅲ+Ⅳ期患者316例,同时选择云南地区汉族健康体检人群384例(对照组),采用Taq Man探针基因分型方法对两组被检者CD40基因中rs1883832(C〉T)和rs4810485(G〉T)2个多态性位点进行基因分型,观察等位基因、基因型及所构建的单倍型在肺癌Ⅰ+Ⅱ期患者、肺癌Ⅲ+Ⅳ期患者和对照组的分布频率。结果:rs4810485位点等位基因G和T在Ⅲ+Ⅳ期肺癌和对照组被检者的分布频率差异具有统计学意义(P=0.013);遗传模式的分析结果经年龄校正后,rs1883832位点在Dominant模式下CC基因型和CT~TT基因型在Ⅰ+Ⅱ期及Ⅲ+Ⅳ期肺癌患者分别与对照组的分布频率比较,差异具有统计学意义(P=0.011和0.008);rs4810485位点在Dominant模式下基因型GG和基因型GT~TTde分布频率比较亦具有统计学意义(P=0.008和0.001)。结论:CD40基因中多态性位点rs4810485位点等位基因G和基因型GG可能是肺癌发生的风险性因素,而rs1883832位点基因型CC可能是肺癌发生的风险因素。 Objective: To investigate the correlation of the single nucleotide polymorphisms (SNPs) (rs1883832 C 〉 T and rs4810485 G 〉 T) in CD40 gene with the occurrence and development of lung cancer in a Yunnan Han population. Methods: A total of 155 lung cancer patients in pathological stages Ⅰ + Ⅱ, 316 lung cancer patients in pathological stages Ⅲ + Ⅳ and 384 healthy individuals were recruited in this study. The genotypes of 2 polymorphism loci (rs1883832 C 〉 T and rs4810485 G 〉 T) of CD40 gene were analyzed by Taqman assay. The distribution frequencies of allele, genotype, and haplotypes in lung cancer patients of pathological stages of Ⅰ + Ⅱ and Ⅲ + Ⅳ, and normal control were observed. Results: The allelic frequencies of G and T at locus rs4810485 in group Ⅲ+ Ⅳ were significantly different from those in control group (P =0. 013 ) , suggesting G at the locus of the allele was the risk factor (OR = 1.33,95% CI: 1.06 - 1.66). The analysis results of inheritance mode showed that under Dominant mode (best fit mode), at locus rs1883832, there were significant differences of frequencies of genotypes CC and CT - Tr between + Ⅱ and control, and between Ⅲ + Ⅳ and control group(P =0.011and 0. 008). In regard of locus rs4810485, under Dominant mode, the distribution frequncies of genotypes of GG and GT - TFde were significantly different between Ⅰ + Ⅱ and control, and between Ⅲ + Ⅳ and control group ( P = 0. 008和 0.001 ). Conclusions: At polymorphism locus rs4810485 of gene CD40, allele G ( OR = 1.33,95% CI: 1.06 ~1.66) and genotype GG( OR = 1.79,95% CI: 1.17 ~ 2.74) might be the risk factors of occurrence of lung cancer. While at locus rs1883832, genotype CC be the risk factor of lung cancer initiation( OR = 1.73,95% CI:1. 13 ~ 2.63).
作者 王小娜 张禹 王培智 周紫云 高雪 杨勤兴 刘舒媛 李传印 史荔 姚宇峰 WANG Xiaona, ZHANG Yu, WANG Peizhi, ZHOU Ziyun, GAO Xue, YANG Qinxing, LIU Shuyuan, LI Chuanyin, SHI Li, YAO Yufeng (Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China)
出处 《贵州医科大学学报》 CAS 2017年第4期383-388,共6页 Journal of Guiyang Medical College
基金 云南省医学学科带头人培养计划(D-201669) 云南省科技厅-昆明医科大学应用基础研究联合专项(2013FB064) 云南省肿瘤内设机构(2014NS139)
关键词 基因型 肺肿瘤 相关性 云南 CD40 genotype lung neoplasm correlation Yunnan CD40
作者简介 通信作者E-mail:leoyyf@gmail.com
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