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温肾养肝方治疗帕金森病非运动症状30例临床研究 被引量:4

A clinical study of 30 cases of non-motor symptoms of Parkinson's disease treated with Wenshenyanggan decoction
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摘要 目的观察温肾养肝方治疗帕金森病非运动症状的疗效。方法将60例患者随机分为两组,对照组(服用抗帕金森西药)和治疗组(同时服用温肾养肝方及抗帕金森西药),每组各30例,治疗4周,对比治疗前后两组非运动症状评分量表(NMSS)和帕金森病问卷-39(PDQ-39)积分进行疗效评估。结果两组患者性别、年龄、病程、病情比较,差异无显著性(P〉0.05),具有可比性。治疗组总有效率高于对照组,两组非运动症状疗效比较差异有显著意义(P〈0.01);治疗组治疗后NMSS及PDQ-39评分与治疗前比较均显著下降(P〈0.05,P〈0.01);治疗后治疗组较对照组NMSS及PDQ-39评分下降,且差异具有统计学意义(P〈0.05,P〈0.01);治疗组治疗前后NMSS的九个领域的严重程度人数分布组内比较,消化道症状在治疗前后分布差异具有统计学意义(P〈0.05),而其余领域比较无统计学意义(P〉0.05)。结论温肾养肝方能够改善帕金森病非运动症状,显著提高患者的生活质量。 Objective To evaluate the efficacy of Wenshenyanggan decoction in treatment of non - motor symptoms (NMS) of Parkinson' s disease. Methods 60 patients of PD were randomly assigned to two groups : 30 in the treatment group ( treated by both Wcnshenyanggan decoction and western medicine) and 30 in the control group (treated only by western medicine). A course of treatment for both groups is 4 weeks. Non -motor symptoms score scale (NMSS) and Parkinsong disease questionnaire -39 ( PDQ - 39) score for efficacy evaluation were observed. Results The differences between two groups in gender, age, duration of illness have no statistically significant ( P 〉 0.05 ). The total efficiency of treatment group was higher than that of control group, and the difference between two groups in curative effect of non - motor symptom has statistical significance ( P 〈 0.05 ). After treatment, NMSS and PDQ - 39 scores of treatment group were significantly decreased (P 〈 O. 05, P 〈 0.01 ). Four weeks later, NMSS and PDQ - 39 scores of treatment group were lower than that of control group, and the difterence has statistical significance (P 〈0.05, P 〈 0.01 ). Conclusion Wenshenyanggan decoction could significantly improve NMS and living quality of PD pa-tients.
作者 陈畅 梁艳 唐莉莉 夏宝妹 唐娟娟 陆艳 赵杨 CHEN Chang1, LIANG Yan1 , TANG Li - li1 ,XIA Bao - mei2 , TANG Juan - juan2 , LU Yan1 , ZHAO Yang1 ( 1. Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210001, China; 2. School of Basic Biomedical Science, Nanjing University of Chinese Medicine, Nanjing 210023, China)
出处 《时珍国医国药》 CSCD 北大核心 2017年第3期636-638,共3页 Lishizhen Medicine and Materia Medica Research
基金 国家自然科学基金(No.81603089) 江苏省中医药管理局课题(No.YB2015060) 江苏省南京市科技发展计划项目(No.20160536)
关键词 帕金森病 非运动症状 温肾养肝方 中医药 Parkinson's disease Non-motor symptoms Wenshenyanggan decoction Chinese medicine
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