Objective To investigate the application effect of TEG in transfusion of patients with coagulant function abnormality after brain tumor surgery. Methods 100 cases with coagulation disorder in our hospital from January 2015 to January 2016 were selected and divided into control group and observation group, 50 cases in each group. Control group was given clinic regular transfusion, observation group was given TEG to detect transfusion. Compare the coagulation condition of the two groups and results of application of TEG after transfusion. Results After transfusion according to TEG results, coagulation condition of observation group was better than control group （P 〈 0. 05 ）. According to detection of TEG after transfusion, each indexes of observation group were better than control group （ P 〈 0. 05 ）. Conclusions After brain tumor surgery, the application of TEG can improve transfusion condition and blood usage condition. It can increase the quality of coagulation, improve rehabilitation efficacy and is worthy of clinic promotion.