期刊文献+

2015年江苏2-7岁儿童接种含腮腺炎成分疫苗后腮腺炎免疫水平研究 被引量:5

Study of mumps immunity after administrating measles-mumps-rubella vaccine among children aged 2-7 years old in jiangsu Province in 2015
分享 导出
摘要 目的 分析2015年江苏2-7岁儿童接种麻疹-腮腺炎-风疹疫苗(MMR)后腮腺炎免疫水平.方法 于2015年9—11月,采用多阶段分层整群随机抽样方法,以常州市武进区、泰州市高港区和连云港赣榆区为研究场所,纳入年龄为2-7岁、在本地至少居住3个月及以上、身体健康并已接种至少1剂次MMR者,并排除未接种MMR、拒绝采集静脉血、经家长或老师回忆已感染过腮腺炎、经临床医生评估身体存在严重疾病或者其他原因不宜参加该研究者后,共获得4190名调查对象.采用自行设计的调查问卷收集调查对象的基本信息及MMR免疫史;采集静脉血0.5-2.0 ml,采用ELISA法定量检测血清中腮腺抗体水平.抗体水平≥108 mU/ml为阳性,〈108 mU/ml则为阴性.采用χ2检验比较不同特征调查对象接种MMR后腮腺炎抗体阳性率差异;采用方差分析比较调查对象仅接种1剂次MMR后不同时间GMC差异.结果 4190名调查对象中,男、女分别为2280(54.42%)和1910(45.58%)名;腮腺炎抗体阳性率为81.38%(3344名);接种1剂次、2剂次和3剂次MMR者分别为3156(95.18%)、187(4.80%)和1(0.02%)名.不同年龄调查对象间腮腺炎抗体阳性率差异有统计学意义(χ2=58.61,P〈0.001),其中4-5岁组较高,为89.43%(406/454),6-7岁组较低,为75.63%(1648/2179).接种1剂次和2剂次MMR调查对象的抗体阳性率分别为79.14%(3156/3988)和93.03%(187/201)(χ2=22.93,P〈0.001);3988名调查对象仅接种1剂次MMR后〈1、1-〈2、2-〈3、3-〈4、≥4年的GMC分别为152.47、227.78、167.08、126.91、79.43 mU/ml(F=51.29,P〈0.001).结论 江苏2-7岁儿童腮腺炎抗体阳性率较高;接种2剂次MMR者腮腺炎抗体阳性率高于仅接种1剂次者,腮腺炎抗体GMC随着时间推移呈下降趋势. Objective To investigate the immunity to mumps after administrating measles-mumps-rubella vaccine (MMR) among children aged 2-7 years old in jiangsu province in 2015. Methods A total of 4190 healthy children aged 2-7 years old, living in local places for at least 3 months, and having been vaccinated at least 1 dose MMR were recruited to the study from Wujin district of Changzhou city, Gaogang district of Taizhou city and Ganyu district of Lianyungang city by using stratified cluster random sampling method between September and November, 2015. Those who did not accept MMR vaccination, who refused venous blood collection, who had affected mumps according to the memory of parents or teachers and who were diagnosed serious disease by clinical doctors were excluded from study. The self-designed questionnaire was used to collect the general information of the subjects and their MMR immunization history;and 0.5-2.0 ml of venous blood was collected from each subject. ELISA was used to detect the mumps antibody level in the serum of patients. Positive was defined as the antibody level ≥108 mU/ml, and negative as〈108 mU/ml.χ2 test was used to compare the difference in positive rates among subjects;and analysis of variance was used to compare the GMC changes in different time points after MMR vaccination. Results Among 4190 children, 2280 were males (54.42%) and 1910 were females(45.58%), and the positive rate of IgG antibody was 81.38% (3344). There were 3156 (95.18%) children vaccinated with one dose MMR, 187 (4.80%) children with two dose MMR, and 1 (0.02%) child with three dose MMR. The difference in positive rate of IgG antibody among different aged subjects showed statistical significance (χ2=58.61, P〈0.001), the highest positive rate was in group of subjects aged 4-5 years old, at 89.43%(406/454), while the lowest positive rate was found among subjects aged 6-7 years old, at 75.63%(1648/2179). The positive rate after one dose of MMR vaccination was 79.14%(3156/3988)
作者 刘元宝 胡莹 邓秀英 汪志国 孙翔 陆培善 郭宏雄 汤奋杨 周明浩 Liu Yuanbao, Hu Ying, Deng Xiuying, Wang Zhiguo, Sun Xiang, Lu Peishan, Guo Hongxiong, Tang Fenyang, Zhou (Minghao Division of Expanded Programme Immunization, jiangsu Center for Disease Control and Prevention, Nanjing 210009, China)
出处 《中华预防医学杂志》 CSCD 北大核心 2017年第7期593-597,共5页 Chinese Journal of Preventive Medicine
基金 国家自然科学基金(81502860) 江苏省重大新发传染病综合防控科技示范工程(BE2015714)
关键词 疫苗 流行性腮腺炎 儿童 抗体阳性率 Vaccines Mumps Child Antibodies positive rate
作者简介 通信作者:刘元宝,Email:lybaomc@163.com; 汤奋扬,Email:tfyepi@163.com
  • 相关文献

参考文献4

二级参考文献52

共引文献66

同被引文献26

引证文献5

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈