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高压氧联合磁刺激、醒脑静对颅脑损伤致昏迷患者的疗效 被引量:2

Clinical Effect of Hyperbaric Oxygen Plus Magnetic Stimulation and Xingnaojing Injection on the Coma Patients with Severe Brain Injury
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摘要 目的:探究高压氧联合磁刺激辅以醒脑静注射液治疗重型颅脑损伤致昏迷患者的临床疗效。方法:根据不同的治疗方法将2011年9月-2016年3月我院收治的120例重型颅脑损伤致昏迷的患者分为观察组和对照组,两组患者均给予神经营养、抗感染、维持电解质平衡等常规外科治疗以及醒脑静注射液治疗,对照组患者在此基础上给予高压氧(HBo)治疗,观察组患者在对照组基础上给予经颅磁刺激(rTMS)治疗。比较两组患者治疗后GCS评分、机体炎症因子、临床预后、记忆功能。结果:治疗后,两组患者GCS评分与治疗前相比均明显上升,观察组患者的GCS评分显著高于对照组(P〈0.05);两组患者的血清C反应蛋白(CRP)、肿瘤坏死因子(TYF-α)、白介素6(IL-6)水平均明显降低,且观察组显著低于对照组(P〈0.05);观察组总有效率为94.55%(52/55),与对照组的总治疗率相当(89.23%,P〉0.05);观察组患者的长期记忆、短期记忆、瞬时记忆评分以及记忆商均显著高于对照组患者(P〈0.05)。结论:高压氧联合磁刺激辅以醒脑静注射液治疗重度脑损伤致昏迷患者的}临床疗效显著,可下调机体炎症因子水平,促进苏醒及记忆功能的恢复。 Objective: To explore the clinical effect of hyperbaric oxygen plus magnetic stimulation and Xingnaojing injection on the coma patients with severe brain injury. Methods: 120 coma patients with severe brain injury who were treated in our hospital from September 2011 to March, 2016 were enrolled in the present study. According to different therapies, they were divided into the observation group (55 cases) and control group (65 cases). Both groups received conventional therapy and Xingnaojing injection, on the the basis of which, the control group received the Hyperbaric Oxygen therapy, while the observation group received Magnetic Stimulation on the basis of control group. The GCS, level of inflammatory factors, clinical prognosis as well as memory function were compared between the two groups. Results: After the therapy, the GCS score of both groups were obviously increased and that of observation group was significantly higher than control group (P〈0.05); the serum level ofCRP, TNF-α, IL-6 levels were significantly decreased compared with those before therapy, and those of observation group were obviously lower than the control group (P 〈 0.05); the total effective rate of observation group was 94.55% (52/55), which was equivalent to the control group (89.23%, P〉0.05); the long term memory, short term memory, instantaneous memory and memory quotient of observation group were significantly higher than those of the control group. Conclusion: Hyperbaric oxygen plus magnetic stimulation and Xingnaojing injectionon was effective on the coma patients with severe brain injury, it could down-regulate the inflammatory response, promote awake and recovery of memory fimction.
作者 孙红星 闫忠军 韩繁龙 曹宁 张国来 SUN Hong-xing1, YAN Zhong-jun2, HAN Fan-long1, CA O Ning1, ZHANG Guo-lai1(1 Department of Surgical, Dongguan Branch of Affiliated Hospital of Yan'an University, Yah'an, Shaanxi, 716000, China; 2 Department of Neurosurgery, Tangdu Hospital, Xi'an, Shaanxi, 710038, China)
出处 《现代生物医学进展》 CAS 2017年第23期4506-4509,共4页 Progress in Modern Biomedicine
关键词 重度颅脑损伤 昏迷 高压氧 磁刺激 醒脑静注射液 Severe brain injury Coma Hyperbaric oxygen Magnetic stimulation Xingnaojing injection
作者简介 孙红星(1981-),男,本科,主治医师,研究方向:高血压脑出血的微创治疗及神经外科重症治疗,电话:13992186500,E—mail:sunhongxing_6500@163.com 通讯作者:张国来(1966-),男,本科,神经外科主任医师,研究方向:颅脑损伤,脑出血,脑膜瘤及胶质瘤的诊治,E—mail:zhangguolai_1966@medthesisonline.com
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