目的探讨比索洛尔对慢性心力衰竭的临床治疗效果。方法 102例慢性心力衰竭患者作为此次研究对象,随机分为治疗组和对照组,各51例。对照组给予低剂量（日用量≤5.00 mg）比索洛尔治疗,治疗组给予高剂量（日用量≥7.50 mg）比索洛尔治疗,比较两组患者临床效果。结果治疗前两组患者的心率、收缩压、舒张压、左室射血分数（LVEF）、左室舒张末期内径（LVEDD）水平、B型利钠肽（BNP）、舒张早期和晚期最大血流速度比（E/A）水平对比差异无统计学意义（P〉0.05）;治疗后两组患者的心率、收缩压、舒张压、LVEF、LVEDD、BNP以及E/A水平均显著改善（P〈0.05）,且治疗组显著优于对照组（P〈0.05）。治疗组患者治疗总有效率为96.1%,明显高于对照组的80.4%,差异具有统计学意义（χ2=6.044,P=0.014〈0.05）。治疗组患者不良反应发生率为9.8%,与对照组的3.9%对比,差异无统计学意义（χ2=1.380,P=0.240〉0.05）。结论比索洛尔治疗慢性心力衰竭患者能够获得较好的临床效果,能够显著提高患者心功能与心肌重构,只要患者能够耐受则应尽量让比索洛尔达到目标剂量治疗,高剂量作用更为显著。
Objective To investigate clinical effect by bisoprolol fumarate（bisoprolol）in the treatment of chronic heart failure. Methods A total of 102 patients with chronic heart failure as study subjects were randomly divided into treatment group and control group, with 51 cases in each group. The control group received low dose（daily dosage ≤ 5.00 mg） of bisoprolol for treatment, and the treatment group received high dose（daily dosage ≥ 7.50 mg） of bisoprolol for treatment（daily dosage ≥ 7.50 mg）. Clinical effects were compared between the two groups. Results There was no statistically significant difference of heart rate, systolic blood pressure, diastolic blood pressure, left ventricular ejection fraction（LVEF）, left ventricular end diastolic dimension（LVEDD）, B-type natriuretic peptide（BNP）, early and late peak diastolic velocity（E/A） before treatment between the two groups（P〈0.05）. After treatment, both groups had obvious improvements in heart rate, systolic blood pressure, diastolic blood pressure, LVEF, LVEDD and E/A（P〈0.05）, and the treatment group had much better indexes than the control group（P〈0.05）. The treatment group had obviously higher total effective rate in treatment as 96.1% than 80.4% in the control group, and the difference had statistical significance（χ2=6.044, P=0.0140.05）. The treatment group had incidence of adverse reactions as 9.8%, which was 3.9% in the control group, and their difference had no statistical significance（χ2=1.380, P=0.2400.05）. Conclusion Bisoprolol shows excellent clinical effect in treating chronic heart failure patients, and it can remarkably improve cardiac function and myocardial remodeling in patients. High dosage shows precise effect, thus patients ought to receive target dosage within their tolerance range.
China Practical Medical