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环孢素联合十一酸睾酮对慢性再生障碍性贫血患者T辅助细胞水平的影响研究 预览 被引量:3

Study on the effect of cyclosporine combined with eleven acid testosterone on serum T helper cells in patients with chronic aplastic anemia
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摘要 目的研究环孢素联合十一酸睾酮对慢性再生障碍性贫血患者T辅助细胞水平的影响。方法选择在该院接受治疗的慢性再生障碍性贫血患者86例作为研究对象,根据患者治疗方案不同分为接受十一酸睾酮联合环孢素治疗的研究组和接受十一酸睾酮治疗的对照组,比较2组患者治疗前后的血常规指标,以及Th1、Th2、Th17、Treg细胞含量。结果治疗前,2组患者间血红蛋白含量、白细胞计数、血小板计数,以及外周血Th1、Th2、Th17、Treg细胞含量的比较,差异无统计学意义(P〉0.05)。治疗2个疗程后,研究组患者的血红蛋白含量、白细胞计数、血小板计数均明显高于对照组。治疗2个疗程、4个疗程后,研究组患者外周血中Th1细胞、Th17的含量明显低于对照组,Th2、Treg细胞的含量明显高于对照组。结论十一酸睾酮联合环孢素治疗能够更为有效地刺激造血、调节免疫功能及T淋巴细胞亚群含量,是治疗慢性再生障碍性贫血的有效方法。 Objective To study the effect of cyclosporine combined with eleven acid testosterone on serum T helper cells in patients with chronic aplastic anemia.Methods A total of 86 patients with chronic aplastic anemia received treatment in our hospital were collected as the research objects,and divided into experimental group and control group,patients in the experimental group received eleven acid testosterone combined with cyclosporine therapy,patients in the control group received eleven acid testosterone therapy.Blood routine indexes,Th1,Th2,Th17 and Treg cells contents of the two groups before and after treatment were compared.Results Before treatment,hemoglobin content,leukocyte count,platelet count,peripheral blood Th1,Th2,Th17 and Treg cells contents of the two groups had no significant difference(P〈0.05).After two courses of treatment,hemoglobin content,leukocyte count,platelet count of the experimental group were significantly higher than those of the control group.After two courses and four courses of treatment,peripheral blood Th1 and Th17contents of experimental group were significantly lower than those of the control group,Th2 and Treg contents were significantly higher than those of the control group.Conclusion Eleven acid testosterone combined with cyclosporine treatment could be more effective to stimulate hematopoiesis,regulate immune function and T lymphocyte subsets content,it′s an effective method for the treatment of chronic aplastic anemia.
作者 李文静 孙宇 赵田华 侯兰芬 王友君 LI Wenjing;SUN Yu;ZHAO Tianhua;HOU Lanfen;WANG Youjun;Department of Hematology,Bethune International Peace Hospital of PLA;
出处 《国际检验医学杂志》 CAS 2017年第15期2088-2090,共3页 International Journal of Laboratory Medicine
关键词 再生障碍性贫血 十一酸睾酮 环孢素 T淋巴细胞 aplastic anemia eleven acid testosterone cyclosporine T lymphocyte
作者简介 李文静,女,主治医师,主要从事血液病的临床研究.
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