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阿托伐他汀联合氯吡格雷对颅内大动脉狭窄进展性脑梗死患者临床疗效 预览 被引量:3

Effect of clopidogrel combined with atorvastatin on NIHSS and Barthel score in patients with progressive cerebral infarction
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摘要 目的:研究阿托伐汀联合氯吡格雷对颅内大动脉狭窄进展性脑梗死患者临床疗效。方法:研究对象选取我院收治的颅内大动脉狭窄进展性脑梗死患者88例,随机分为研究组和研究组,每组各44例。对照组患者口服氯吡格雷治疗,在此基础上研究组患者加用阿托伐他汀治疗,所有患者均连续治疗4周。比较两组患者的治疗总有效率、不良反应发生率及血脂水平,同时比较两组治疗前后的神经功能缺损(NIHSS)评分和日常生活能力(ADL)评分。结果:研究组的治疗总有效率明显高于对照组(P〈0.05);治疗后,研究组的NIHSS评分明显低于对照组(P〈0.01),BI指数明显高于对照组(P〈0.01);研究组LDL-C、TG、TC均显著低于对照组,HDL-C显著高于对照组(P〈0.05),两组不良反应发生率比较无明显差异(P〉0.05)。结论:氯吡格雷联合阿托伐他汀对颅内大动脉狭窄SIP患者的疗效显著,改善患者神经功能及生活质量且安全可靠,值得临床推广。 Objective:To study the clinical effect of atorvastatin combined with clopidogrel on patients with progressive cerebral infarction of intracranial aortic stenosis.Methods:A total of eighty-eight patients with progressive cerebral infarction in our hospital from June 2014 to October 2015 were selected.They were randomly divided into control group and study group,44 cases in each group.The patients in the control group were treated with oral clopidogrel.On the basis of this,the patients in the study group were treated with atorvastatin.All patients were treated for 4weeks.The total effective rate,adverse reaction rate,coagulation function index and blood lipid level between the two groups were compared,and the NIHSS score and daily life ability(ADL)score between the two groups before and after treatment were also compared.Results:The total effective rate(90.90%)was significantly higher in the study group than in the control group(72.73%)(χ^2=4.88,P=0.02).After treatment,the NIHSS score of the study group was significantly lower than that of the control group(P〈0.01).The levels of LDL-C,TG and TC in the study group were significantly lower than those in the control group,and HDL-C was significantly higher than that in the control group(P〈0.05).There was no significant difference between the two groups(P〉0.05).Conclusion:Clopidogrel combined with atorvastatin has a significant effect on the patients with intracranial large artery stenosis and improves the neurological function and quality of life.It is safe and reliable.It is worthy of popularization.
作者 张晓艳 沈建昀 张生 张国欣 ZHANG Xiao-yan1 , SHEN Jian-yun2 , ZHANG Sheng3 , ZHANG Guo-xin3 (1.Zunhua People's Hospital, Tangshan City, Hebei Province 064200; 2. Xianghe County People's Hospital, Langfang City, Hebei Province 065400; 3. Qianxi County People's Hospital, Tangshan City, Hebei Province 064300)
出处 《海南医学院学报》 CAS 2017年第12期1726-1729,共4页 Journal of Hainan Medical College
基金 河北省卫生厅课题项目(20171399)
关键词 氯吡格雷 阿托伐他汀 进展性脑梗死 NIHSS评分 ADL评分 颅内大动脉狭窄 Clopidogrel Atorvastatin Progressive cerebral infarction NIHSS score ADL score Intracranial large artery stenosis
作者简介 张晓艳(1976),女,河北唐山人,本科,主治医师。E—mail:gtcc14251@163.com。
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