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不同丙泊酚复合舒芬太尼给药方案在人工流产术中抑制体动的效果比较 预览 被引量:1

Comparative Study of the Effect of Different Propofol Combined with Sufentanil Regimens Suppressing Body Motion during Induced Abortion
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摘要 目的 比较不同丙泊酚复合舒芬太尼给药方案在人工流产术中抑制体动的效果。方法 选取2014年1月至2015年5月延安市人民医院120例早期妊娠患者为研究对象,采用随机数字法分成对照组和观察组,每组60例。对照组给予人工静脉推注舒芬太尼1μg/kg,1 min后静脉推注丙泊酚1.0~1.5μg/kg,以4 mg/s术中间隔推注;观察组靶控输注丙泊酚复合舒芬太尼,首次剂量为2μg/mL,入睡后以1.8μg/mL速度输注。观察两组麻醉疼痛情况,两组相关时间和药物用量,以及麻醉后并发症情况。结果 观察组术中镇痛和术后宫缩痛效果均优于对照组(P〈0.05)。观察组扩宫刮宫时间、苏醒时间、丙泊酚用量明显低于对照组[(5.7±0.8)min比(7.7±0.9)min,(3.4±0.5)min比(4.8±0.8)min,(71.6±7.8)mg比(129.5±26.7)mg],而舒芬太尼用量明显高于对照组[(20.9±5.4)mg比(32.1±6.4)mg](P〈0.01)。观察组体动、嗜睡乏力、头晕、恶心呕吐发生率分别为5.0%(3/60)、3.3%(2/60)、3.3%(2/60)、3.3%(2/60),低于对照组的30.0%(15/60)、15.0%(9/60)、18.3%(11/60)、20.0%(12/60)(P〈0.05)。结论 靶控输注丙泊酚复合舒芬太尼对人工流产术中抑制体动效果好,术后恢复迅速。 Objective To investigate the effect of different propofol combined with sufentanil regimens on the inhibition of body motion during abortion. Methods From Jan. 2014 to May 2015,120 patients with early pregnancy in Yan' an People's Hospital were selected as the subjects,and divided into a control group and an observation group according to the random number method,60 cases each. The control group received intravenous injection of sufentani l μg/kg,and propofol1-1. 5 μg/kg 1 min later,with 4 mg/s intraoperative interval injection; the observation group received target-controlled infusion of propofol combined with sufentanil for the first time,at the dose of 2 μg/mL,then at the speed of 1. 8 μg/mL after falling asleep. The anesthesia pain,related time and dosage,and the complications after anesthesia of the two groups were observed. Results Intraoperative analgesia and uterine contraction pain effect of the observation group were better than that of the control group( P 0. 05). The dilatation and curettage time,recovery time,propofol dosage of the observation group were significantly lower than those of the control group[( 5. 7 ± 0. 8) min vs( 7. 7 ± 0. 9) min,( 3. 4 ± 0. 5) min vs( 4. 8 ±0. 8) min,( 71. 6 ± 7. 8) mg vs( 129. 5 ± 26. 7) mg],the dosage of sufentanil was higher than that of the control group[( 20. 9 ± 5. 4) mg vs( 32. 1 ± 6. 4) mg]( P 0. 01). The incidence of body movement,lethargy,dizziness,nausea and vomiting in the observation group were 5. 0%( 3/60),3. 3%( 2/60),3. 3%( 2/60),3. 3%( 2/60),lower than those of the control group[30. 0%( 15/60),15. 0%( 9/60),18. 3%( 11/60),20. 0%( 12/60) ]( P 0. 05). Conclusion Targetcontrolled infusion of propofol combined with sufentanil has a good body inhibitory effect on induced abortion with rapid recovery after operation.
作者 李世多 白文娟 马涛 张侃 LI Shiduo1 , BAI Wenjuan2, MA Tao2, ZHANG Kan1. ( 1. Department of Anesthesia, Yan'an People's Hospital, Yan' an 716000, China; 2. Department of Anesthesia, Affiliated Hospital of Yan' an University, Yan'an 716000, China)
出处 《医学综述》 2017年第19期3950-3952,F0003共4页 Medical Recapitulate
关键词 靶控输注 丙泊酚 舒芬太尼 人工流产 体动 Target-controlled infusion Propofol Sufentanil Abortion Body motion
作者简介 通信作者E-mail:lishiduoyy@163.com
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