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多发性骨髓瘤并发心肾淀粉样变性一例报道并文献复习 预览 被引量:1

Multiple Myeloma Complicated with Cardiac and Renal Amyloidosis: a Case Report and Literature Review
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摘要 多发性骨髓瘤是恶性浆细胞病中的常见类型,主要特点为单克隆浆细胞在骨髓中恶性增生并广泛浸润,常伴有血/尿中大量单克隆免疫球蛋白/轻链的分泌。可并发淀粉样变性,因淀粉样物质沉积而累及重要的组织器官,临床上较为罕见,患者多预后不良。本文报道了1例多发性骨髓瘤并发心肾淀粉样变性的患者,并对相关文献进行了复习。提示临床医生遇到表现为多脏器受累的疾病时需考虑淀粉样变性的可能,同时考虑到多发性骨髓瘤并发淀粉样变性的可能,提高对该病的认识,做到早期诊断和治疗,改善患者预后。 Multiple myeloma( MM) is a common malignant plasma cell disease,which is characterized by malignant proliferating and infiltrating of monoclonal plasma cells in the bone marrow and often accompanied by secretion of a larger number of monoclonal immunoglobulins/monoclonal immunoglobulin light chains in blood/urine. MM can be complicated with amyloidosis associated with amyloid depositing in important tissues and organs,which is rare,and most likely the patient will have a poor prognosis. We reported one case of MM complicated with cardiac and renal amyloidosis,and reviewed the related literature,in order to improve the awareness level for the disease,remind clinicians that a patient may have amyloidosis or MM with amyloidosis if he has a disease with multiple organ involvement,by which timely diagnosis and treatment can be performed and the prognosis can be improved.
作者 胡静 刘作良 张浩 HU Jin g ,LIU Zuo-liaag2, ZHANG Hao'1(1. Department of Nephrology , The Third Xiangya Hospital of Central South University , Changsha 4 1 0 0 1 3 , China2. Intensive Care Unit , The Third Xiangya Hospital of Central South University , Changsha 4 1 0 0 1 3 , China)
出处 《中国全科医学》 北大核心 2017年第34期4335-4338,共4页 Chinese General Practice
关键词 多发性骨髓瘤 淀粉样变性 Mul tiple myeloma Amy lo idos is
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