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柏艾胶囊改善高血压伴代谢综合征病人胰岛素抵抗及糖脂代谢的临床研究 预览 被引量:1

Clinical Reseach on Baiai Capsule for Improving Insulin Resistance and Glycolipid Metabolism in Hypertensive Patients Complicated with Metabolic Syndrome
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摘要 目的研究柏艾胶囊联合常规疗法对高血压伴代谢综合征(MS)病人胰岛素抵抗、糖脂代谢的影响。方法将74例符合入选标准的病人随机分为治疗组(基础治疗+柏艾胶囊)34例与对照组(基础治疗+安慰剂)40例,两组均治疗12周。观察两组病人治疗前后形体学指标、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、糖脂代谢的变化。结果治疗组治疗后体重指数(BMI)、HOMA-IR、餐后2h血糖(2hPPG)、三酰甘油(TG)较治疗前显著下降,高密度脂蛋白胆固醇(HDL-C)较治疗前显著升高,差异有统计学意义(P〈0.05),空腹血糖(FPG)、糖化血红蛋白(HbA1c)、FINS较治疗前下降,但差异无统计学意义(P〉0.05);对照组治疗后BMI、FPG、2hPPG和HOMA-IR较治疗前有所下降,但差异无统计学意义(P〉0.05);对照组治疗后HOMA-IR、血脂、血糖较治疗前有所改善,但差异无统计学意义(P〈0.05);两组治疗后BMI、TG及HDL-C差异有统计学意义(P〈0.05),HOMA-IR和血糖相关指标差异无统计学意义(P〉0.05)。结论柏艾胶囊可以降低MS病人的胰岛素抵抗,并可明显改善病人的糖脂代谢及中心性肥胖,在降压的同时减少高血压的相关危险因素。 Objective To investigate the effect of Baiai capsule(BAC)and routine treatment on insulin resistance and glycolipid metabolism in hypertensive patients complicated with metabolic syndrome(MetS).Methods Seventy-four hypertensive patients complicated with MetS were randomly divided into control group(n =40)treated with placebo plus routine treatment,and treatment group(n =34)treated with BAC plus routine treatment for 12 weeks.The changes of blood pressure,steady-state insulin resistance index,blood glucose,glycosylated hemoglobin(HbA1 c),blood lipid,physical index,clinical symptoms and signs and safety indexes were observed during the treatment.Results After treatment,the levels of body mass index(BMI),2 h postprandial glucose(2 h PPG)and homeostatic model assessment of insulin resistance(HOMA-IR)in treatment group were significantly lower than those before(P〈0.05).There was no significant difference in fasting plasma glucose(FPG),HbA1 c and fasting insulin(FINS),but it showed a downward trend.Triglycerides(TG)level was decreased significantly in treatment group while high-density lipoprotein cholesterol(HDL-C)level was increased significantly(P〈0.05).There was significant difference in BMI,TG and HDL-C between two groups after treatment(P〈0.05).Conclusion BAC can reduce HOMA-IR,improve insulin resistance and body mass index,and regulate glucose and lipid metabolism in hypertensive patients complicated with MetS.
作者 韩亚楠 陈曦 符德玉 芦波 周训杰 桂明泰 姚磊 李建华 龙敏 舒婷 董振华 石亚楠 Han Yanan, Chen Xi, Fu Deyu, Lu Bo, Zhou Xunjie, Gui Mingtai, Yao Lei, Li Jianhua, Long Min, Shu Ting, Dong Zhenhua, Shi Yanan(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai 200437, China)
出处 《中西医结合心脑血管病杂志》 2018年第1期25-27,共3页 Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease
基金 上海市中西医结合学会科研基金项目(No.SHB201402) 上海市进一步加快中医药事业发展三年行动计划(2014年—2016年)资助项目(No.ZY3-CCCX-3-3026)
关键词 高血压 代谢综合征 胰岛素抵抗 柏艾胶囊 糖脂代谢 hypertension metabolic syndrome insulin resistance Baiai capsule glycolipid metabolism
作者简介 通讯作者:符德玉,Email:fdy65@126.com
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